1. Gene
  2. LTBR - lymphotoxin beta receptor Gene

LTBR - lymphotoxin beta receptor Gene

Homo sapiens

Also known as TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III

Gene ID: 4055 | Gene type: protein coding

About LTBR

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,375,160-6,391,566 (from NCBI)

This gene has 15 transcripts (splice variants), 546 orthologues and 21 paralogues. Ubiquitous expression in prostate (RPKM 23.4), placenta (RPKM 23.0) and 25 other tissues.

Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

LTBR Products(12)

mRNA Protein Name
NM_001270987.2 NP_001257916.1 tumor necrosis factor receptor superfamily member 3 isoform 2
NM_001414303.1 NP_001401232.1 tumor necrosis factor receptor superfamily member 3 isoform 3 precursor
NM_001414304.1 NP_001401233.1 tumor necrosis factor receptor superfamily member 3 isoform 4 precursor
NM_001414305.1 NP_001401234.1 tumor necrosis factor receptor superfamily member 3 isoform 5 precursor
NM_001414306.1 NP_001401235.1 tumor necrosis factor receptor superfamily member 3 isoform 6 precursor
NM_001414307.1 NP_001401236.1 tumor necrosis factor receptor superfamily member 3 isoform 7 precursor
NM_001414308.1 NP_001401237.1 tumor necrosis factor receptor superfamily member 3 isoform 8 precursor
NM_001414309.1 NP_001401238.1 tumor necrosis factor receptor superfamily member 3 isoform 9
NM_001414310.1 NP_001401239.1 tumor necrosis factor receptor superfamily member 3 isoform 10 precursor
NM_001414311.1 NP_001401240.1 tumor necrosis factor receptor superfamily member 3 isoform 11 precursor
NM_001414312.1 NP_001401241.1 tumor necrosis factor receptor superfamily member 3 isoform 12 precursor
NM_002342.3 NP_002333.1 tumor necrosis factor receptor superfamily member 3 isoform 1 precursor

LTBR Protein Structure

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (43 - 80)

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (83 - 124)

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  • 435 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 3

lymphotoxin B receptor

Recombinant LTBR Proteins

Cat. No. Product Name Accession Purity
HY-P70345 TNFRSF3/LTBR Protein, Human (HEK293, His) P36941 (Q31-M227) ≥95%
HY-P72806 TNFRSF3/LTBR Protein, Human (HEK293, Fc) P36941 (Q31-M227) ≥95%

Related Diseases

Diseases Alias
External Ear Basal Cell Carcinoma

Basal Cell Carcinoma Of External Ear

Basal Cell Carcinoma Of The External Ear

External Ear Squamous Cell Carcinoma

Epidermoid Carcinoma Of The External Ear

Squamous Cell Carcinoma Of External Ear

External Ear Carcinoma

Carcinoma Of External Ear

Carcinoma Of The External Ear

Bone Squamous Cell Carcinoma
Inflammatory Bowel Disease 18

IBD18

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris LTBR VGNC VGNC:42860
Bos taurus LTBR VGNC VGNC:31075
Mus musculus LTBR MGD MGI:104875
Felis catus LTBR VGNC VGNC:68105
Macaca mulatta LTBR VGNC VGNC:100075
Rattus norvegicus LTBR RGD RGD:1309448
Macaca fascicularis LTBR NCBI
Others LTBR NCBI