ZMYND11 - zinc finger MYND-type containing 11 Gene

Also Known as BS69; BRAM1; MRD30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10771

About ZMYND11

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:130,088-254,637 (from NCBI)

This gene has 26 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 38.3), brain (RPKM 25.5) and 25 other tissues.

Summary

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ZMYND11 Products (36)

mRNA Protein Name
NM_001202464.3 NP_001189393.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001202465.3 NP_001189394.1 zinc finger MYND domain-containing protein 11 isoform d
NM_001202466.3 NP_001189395.1 zinc finger MYND domain-containing protein 11 isoform e
NM_001202467.1 NP_001189396.1 zinc finger MYND domain-containing protein 11 isoform f
NM_001202468.1 NP_001189397.1 zinc finger MYND domain-containing protein 11 isoform g
NM_001330057.3 NP_001316986.1 zinc finger MYND domain-containing protein 11 isoform h
NM_001370097.3 NP_001357026.1 zinc finger MYND domain-containing protein 11 isoform a
NM_001370098.2 NP_001357027.1 zinc finger MYND domain-containing protein 11 isoform a
NM_001370099.2 NP_001357028.1 zinc finger MYND domain-containing protein 11 isoform a
NM_001370100.5 NP_001357029.1 zinc finger MYND domain-containing protein 11 isoform a
NM_001370101.2 NP_001357030.1 zinc finger MYND domain-containing protein 11 isoform a
NM_001370102.2 NP_001357031.1 zinc finger MYND domain-containing protein 11 isoform a
NM_001370103.2 NP_001357032.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370104.2 NP_001357033.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370105.2 NP_001357034.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370106.2 NP_001357035.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370107.2 NP_001357036.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370108.2 NP_001357037.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370109.2 NP_001357038.1 zinc finger MYND domain-containing protein 11 isoform c
NM_001370110.2 NP_001357039.1 zinc finger MYND domain-containing protein 11 isoform d
NM_001370111.2 NP_001357040.1 zinc finger MYND domain-containing protein 11 isoform e
NM_001370112.2 NP_001357041.1 zinc finger MYND domain-containing protein 11 isoform h
NM_001370113.2 NP_001357042.1 zinc finger MYND domain-containing protein 11 isoform i
NM_001370114.2 NP_001357043.1 zinc finger MYND domain-containing protein 11 isoform i
NM_001370115.2 NP_001357044.1 zinc finger MYND domain-containing protein 11 isoform j
NM_001370116.2 NP_001357045.1 zinc finger MYND domain-containing protein 11 isoform k
NM_001370117.2 NP_001357046.1 zinc finger MYND domain-containing protein 11 isoform l
NM_001370118.2 NP_001357047.1 zinc finger MYND domain-containing protein 11 isoform m
NM_001370119.2 NP_001357048.1 zinc finger MYND domain-containing protein 11 isoform n
NM_001370120.2 NP_001357049.1 zinc finger MYND domain-containing protein 11 isoform o
NM_001370121.2 NP_001357050.1 zinc finger MYND domain-containing protein 11 isoform p
NM_001370122.2 NP_001357051.1 zinc finger MYND domain-containing protein 11 isoform q
NM_001370123.2 NP_001357052.1 zinc finger MYND domain-containing protein 11 isoform r
NM_001370124.3 NP_001357053.1 zinc finger MYND domain-containing protein 11 isoform s
NM_006624.7 NP_006615.2 zinc finger MYND domain-containing protein 11 isoform a
NM_212479.4 NP_997644.2 zinc finger MYND domain-containing protein 11 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
24675531 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
24675531 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10734313 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
24675531 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
26845565 GOA
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
20732415 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
20732415 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
20732415 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24675531 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYND11 Protein Structure

Bromodomain

Bromodomain: Bromodomain (182 - 242)

PWWP

PWWP: PWWP domain (281 - 351)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

zinc finger MYND domain-containing protein 11

  • adenovirus 5 E1A-binding protein

ZMYND11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZMYND11 Q15326 ZHX1 Homo sapiens Q9UKY1
Phage Display
35044719
Intra
ZMYND11 Q15326 LTBR Homo sapiens P36941
Y2H
20732415
Intra
ZMYND11 Q15326 LTBR Homo sapiens P36941
Anti Tag CoIP
20732415
Intra
ZMYND11 Q15326 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
20138174
Cross
ZMYND11 Q15326 e1a_ade05 Human adenovirus C P03255
Pull Down
11733528
Cross
ZMYND11 Q15326 e1a_ade05 Human adenovirus C P03255
Anti Bait CoIP
11733528
Cross
ZMYND11 Q15326 LMP1 Epstein-Barr virus P03230
Anti Tag CoIP
20138174
Cross
ZMYND11 Q15326 EBNA2 Epstein-Barr virus P12978
Anti Bait CoIP
11733528
Cross
ZMYND11 Q15326 EBNA2 Epstein-Barr virus P12978
Pull Down
11733528
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 30, With Speech Delay And Behavioral Abnormalities

  • MRD30

  • Mental Retardation, Autosomal Dominant 30

  • Intellectual Developmental Disorder, Autosomal Dominant 30

  • Autosomal Dominant Non-Syndromic Intellectual Disability 30

  • Autosomal Dominant Intellectual Developmental Disorder 30

  • Autosomal Dominant Mental Retardation 30

  • Mental Retardation, Autosomal Dominant, Type 30
Autosomal Dominant Intellectual Disability 30

  • Intellectual Disability, Autosomal Dominant 30
Autosomal Dominant Non-Syndromic Intellectual Disability
Fibrodysplasia Ossificans Progressiva

  • Myositis Ossificans Progressiva

  • Progressive Myositis Ossificans

  • FOP

  • Progressive Ossifying Myositis

  • Myositis Ossificans

  • Stone Man Syndrome

  • Man Of Stone

  • Myositis Ossificans Progressive

  • Diffuse Progressive Ossifying Polymyositis

  • Fibrodysplasia Ossificans Congenita

  • Myositis Ossificans Progressiva, Site Unspecified

  • Münchmeyer Disease

  • Fop - [Fibrodysplasia Ossificans Progressiva]

  • Progressive Myositis Ossificans Calcification
Hypoparathyroidism-Deafness-Renal Disease Syndrome

  • Barakat Syndrome

  • Hypoparathyroidism, Deafness, Renal Disease Syndrome

  • Hdr Syndrome

  • Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Familial Cold Autoinflammatory Syndrome 3

  • Plaid

  • Familial Atypical Cold Urticaria

  • Facu

  • FCAS3

  • Antibody Deficiency And Immune Dysregulation, Plcg2-Associated

  • Plcg2-Associated Antibody Deficiency And Immune Dysregulation

  • Familial Cold Urticaria With Common Variable Immunodeficiency

  • Plcg2 Associated Antibody Deficiency And Immune Dysregulation

  • Antibody Deficiency And Immune Dysregulation Placg2-Associated

  • Autoinflammatory Syndrome, Cold, Familial, Type 3
Ptosis

  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris
Nephronophthisis 3

  • NPHP3

  • Nph3

  • Adolescent Nephronophthisis

  • Nephronophthisis, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16094 ZMYND11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZMYND11 MGD MGI:1913755
Macaca mulatta ZMYND11 VGNC VGNC:79060
Bos taurus ZMYND11 VGNC VGNC:37202
Rattus norvegicus ZMYND11 RGD RGD:1303252
Canis familiaris ZMYND11 VGNC VGNC:48651
Others ZMYND11 NCBI