Makorin-2 Antibody (YA10076)
(Synonyms: Bardet-Biedl syndrome 4 protein)Makorin-2 Antibody (YA10076) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Makorin-2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:10-50 | 1:10-50 |
Product Details
Makorin-2 Antibody (YA10076) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Makorin-2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 46 kDa
Purified recombinant protein of human Makorin-2.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Makorin-2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity)
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_Specificity: Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level). Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen. -
Isoforms & Post-Translational Modification
Makorin-2 has 2 isoforms, Q9H000-1: amino acid length is 416, molecular weight is 46940 Da (predicted); Q9H000-2: amino acid length is 373, molecular weight is 41985 Da (predicted).
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Subunit
Interacts with PDLIM2 (via LIM zinc-binding domain) (By similarity).
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SwissProt ID
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Synonyms
Bardet-Biedl syndrome 4 protein
Documentation
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