2. Gene
  3. MKRN2 - makorin ring finger protein 2 Gene

MKRN2 - makorin ring finger protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RNF62; HSPC070

Gene ID: 23609 | Gene type: protein coding

About MKRN2

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,557,087-12,583,713 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 30.6), thyroid (RPKM 16.5) and 25 other tissues.

Summary

This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

MKRN2 Products(2)

mRNA Protein Name
NM_001271707.2 NP_001258636.1 E3 ubiquitin-protein ligase makorin-2 isoform 2
NM_014160.5 NP_054879.3 E3 ubiquitin-protein ligase makorin-2 isoform 1

MKRN2 Protein Structure

zf-CCCH_2

zf-CCCH_2: RNA-binding, Nab2-type zinc finger (8 - 26)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (36 - 55)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (169 - 191)

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (238 - 291)

zf-CCCH_2

zf-CCCH_2: RNA-binding, Nab2-type zinc finger (333 - 348)

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  • 416 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase makorin-2

RING finger protein 62

Related Diseases

Diseases Alias
Oligoasthenoteratozoospermia

Oat

Oligoasthenoteratospermia
Central Precocious Puberty

Cpp

Gonadotropin-Dependant Precocious Puberty

Gonadotropin-Dependent Precocious Puberty

Precocious Puberty, Central
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08480 MKRN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MKRN2 VGNC VGNC:68266
Rattus norvegicus MKRN2 RGD RGD:1310618
Mus musculus MKRN2 MGD MGI:1914277
Bos taurus MKRN2 VGNC VGNC:55064
Canis familiaris MKRN2 VGNC VGNC:43252
Macaca mulatta MKRN2 VGNC VGNC:74878