NKp30 Antibody (YA1471)
(Synonyms: NCR3; CD337; NKp30; 1C7; LY117; MALS)NKp30 Antibody (YA1471) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NKp30.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in sterile PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:50-1:100 | 1:10000 |
Product Details
NKp30 Antibody (YA1471) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NKp30.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
Recombinant human NKp30 protein
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in sterile PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NKp30 cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is selectively expressed in all resting and activated NK cells, with weaker expression in the spleen. -
Isoforms & Post-Translational Modification
O14931 has 6 isomers: O14931-1: 21593 Da (predicted); O14931-2: 20640 Da (predicted); O14931-3: 19237 Da (predicted); O14931-4: 18749 Da (predicted); O14931-5: 17796 Da (predicted); O14931-6: 16393 Da (predicted).
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Subunit
Homodimer in the unliganted form (PubMed:21422170, PubMed:21444796). Interacts with CD3Z (PubMed:10562324, Ref.2). Interacts with and is activated by binding to NCR3LG1 (PubMed:19528259, PubMed:21422170, PubMed:21444796). Interacts with and is activated by binding to BAG6 (PubMed:18055229, PubMed:18852879). Interacts with and is inhibited by binding to LGALS3 (PubMed:25315772)
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SwissProt ID
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Synonyms
NCR3; CD337; NKp30; 1C7; LY117; MALS
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Research Field
Immunology
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