NCR3 - natural cytotoxicity triggering receptor 3 Gene

Also Known as 1C7; MALS; CD337; LY117; NKp30

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 259197

About NCR3

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,588,895-31,593,006 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 590 orthologues, 14 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 5.8), spleen (RPKM 4.7) and 18 other tissues.

Summary

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

NCR3 Products (3)

mRNA	Protein	Name
NM_001145466.2	NP_001138938.1	natural cytotoxicity triggering receptor 3 isoform b precursor
NM_001145467.2	NP_001138939.1	natural cytotoxicity triggering receptor 3 isoform c precursor
NM_147130.3	NP_667341.1	natural cytotoxicity triggering receptor 3 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21444796	GOA
enables immune receptor activity	IDA IDA: Inferred from direct assay	15294952	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18055229	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NK T cell activation	IDA IDA: Inferred from direct assay	15294952	GOA
involved in immune response-activating cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	18852879	GOA
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	18852879	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16304049	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	15294952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR3 Protein Structure

V-set

0
100
201 a.a.

Protein Preferred Names	Protein Names
natural cytotoxicity triggering receptor 3	NK-p30

NCR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCR3	O14931	LGALS3	Homo sapiens	P17931	Anti Bait CoIP	25315772
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	SPR	21444796
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	SPR	19528259
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	SPR	21422170
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	FACS	22807449
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	X-Ray Diffraction	21422170
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	Crosslink	19528259
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	SPR	27754869
Intra	NCR3	O14931	NCR3LG1	Homo sapiens	Q68D85	SPR	22807449
Intra	NCR3	O14931	NCR3	Homo sapiens	O14931	EM	24275655
Intra	NCR3	O14931	NCR3	Homo sapiens	O14931	GMS	24275655
Intra	NCR3	O14931	NCR3	Homo sapiens	O14931	Electrophoresis	22807449
Intra	NCR3	O14931	NCR3	Homo sapiens	O14931	X-Ray Diffraction	21444796
Intra	NCR3	O14931	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	NCR3	O14931	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	NCR3	O14931	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	NCR3	O14931	BAG6	Homo sapiens	P46379	ELISA	22807449
Intra	NCR3	O14931	BAG6	Homo sapiens	P46379	ELISA	18852879

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72506	NKp30/NCR3 Protein, Human (HEK293, His)	O14931-1 (L19-T138)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77811	NKp30/NCR3 Protein, Human (HEK293, Fc)	O14931-1 (L19-T138)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77812	NKp30/NCR3 Protein, Human (HEK293, His-Avi)	O14931-1 (L19-T138)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77813	NKp30/NCR3 Protein, Human (Biotinylated, HEK293, His-Avi)	O14931-1 (L19-T138)	≥ 95%, as determined by Bis-Tris PAGE.

NCR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81726	NKp30 Antibody (YA1471)	FC, ELISA	Human
HY-P83817	NKp30 Antibody (YA3514)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P83817A	NKp30 Antibody (YA3514)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84990	NKp30 Antibody (YA4682)	ELISA, FC	Human

Related Diseases

Diseases	Alias
Malaria, Mild	Malaria, Mild, Susceptibility To Mals Mal Xx Males Karyotype 47,Xyy Double Y Syndrome Xyy Syndrome
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Nk Cell Deficiency
Bronchiectasis 1
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09100	NCR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09101	NCR3LG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25850	Ncr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27148	Ncr3lg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29456	Ncr3lg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NCR3	VGNC	VGNC:74990
Canis familiaris	NCR3	VGNC	VGNC:43666
Mus musculus	NCR3	MGD	MGI:2149332
Bos taurus	NCR3	VGNC	VGNC:31927
Rattus norvegicus	NCR3	RGD	RGD:727881
Others	NCR3	NCBI