NKp30 Antibody (YA4682)

Cat. No.: HY-P84990: Data Sheet User Guide for Antibodies
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NKp30 Antibody (YA4682) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp30.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NKp30 Antibody (YA4682) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp30.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

O14931

Gene ID

259197 [NCBI]

Immunogen

Purified recombinant Human CD337

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-100000
FC FC: Flow Cytometry	1-2μg/Test

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation

Subcellular Localization：Cell membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It is selectively expressed in all resting and activated NK cells, with weaker expression in the spleen.

Isoforms & Post-Translational Modification：O14931 has 6 isomers: O14931-1: 21593 Da (predicted); O14931-2: 20640 Da (predicted); O14931-3: 19237 Da (predicted); O14931-4: 18749 Da (predicted); O14931-5: 17796 Da (predicted); O14931-6: 16393 Da (predicted).

Subunit：Homodimer in the unliganted form (PubMed:21422170, PubMed:21444796). Interacts with CD3Z (PubMed:10562324, Ref.2). Interacts with and is activated by binding to NCR3LG1 (PubMed:19528259, PubMed:21422170, PubMed:21444796). Interacts with and is activated by binding to BAG6 (PubMed:18055229, PubMed:18852879). Interacts with and is inhibited by binding to LGALS3 (PubMed:25315772)

Synonyms

1C7 antibody; Activating natural killer receptor p30 antibody; Activating NK A1 receptor antibody; CD337 antibody; CD337 antigen antibody; LY117 antibody; Lymphocyte antigen 117 antibody; MALS antibody; Natural cytotoxicity triggering receptor 3 antibody; Natural killer cell p30 related protein antibody; Natural killer cell p30-related protein antibody; Ncr3 antibody; NCTR3_HUMAN antibody; NK-p30 antibody; NKp30 antibody; CD337 nanobody;

Documentation

User Guide for Antibodies (1077 KB)