Noggin Antibody (YA698)

Cat. No.: HY-P80767: FAQs
Data Sheet User Guide for Antibodies

Noggin Antibody (YA698) is a non-conjugated and Mouse origined monoclonal antibody about 26 kDa, targeting to Noggin (1D2). It can be used for WB,ICC/IF assays with tag free, in the background of Transfected.

For research use only. We do not sell to patients.

Size	Price	Stock
10 μL	$70	Ask For Quote & Lead Time
50 μL	$185	Ask For Quote & Lead Time
100 μL	$300	Ask For Quote & Lead Time

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Biological Activity
Technical Parameters
Properties
Documentation

Description	Noggin Antibody (YA698) is a non-conjugated and Mouse origined monoclonal antibody about 26 kDa, targeting to Noggin (1D2). It can be used for WB,ICC/IF assays with tag free, in the background of Transfected.
Background	Noggin (1D2): The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
Tag	Free
Gene ID	9241
Synonyms	SYM1; SYNS1.
Molecular Weight	Predicted band size: 26 kDa
Purity	affinity purified
Conjugation	Non-conjugated
Research Field	Stem Cells
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Host	Mouse
Reactivity	Transfected（Human, Mouse, Rat）
SwissProt ID	Q13253
Dilution Ratio	WB: 1:500-1:1,000 ;IF: 1:50-1:200
Application	WB, ICC/IF
Appearance	Liquid
Formulation	Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG3
Immunogen	Synthetic peptide corresponding to Human Noggin.The exact sequence is proprietary to MCE.
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Noggin Antibody (YA698)

Biological Activity

Technical Parameters

Properties

Documentation

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