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Noggin Antibody (YA698)

(Synonyms: SYM1; SYNS1.)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Noggin Antibody (YA698) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to Noggin.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG3

  • Application:

    WB, ICC/IF

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Noggin Antibody (YA698)
  • Noggin Antibody (YA698) Product Image
  • Experimental Validation Results for Noggin Antibody (YA698)
  • Noggin Antibody (YA698) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Noggin Antibody (YA698)

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Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:500-1:1000 1:50-1:200

Product Details

Description

Noggin Antibody (YA698) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to Noggin.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 26 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 26 kDa
Species Reactivity Database
Immunogen

Synthetic peptide corresponding to Human Noggin.The exact sequence is proprietary to MCE.

Sensitivity

Transfected

Purification

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG3

RRID

AB_3102702

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Noggin Antibody (YA698)
    Western blot analysis of extracts from Hela (lane 2(20μg), Hela (lane 3(40μg), using Noggin Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732)

  • Subcellular Localization

    Secreted

  • Subunit

    Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation

  • SwissProt ID

    Q13253

  • Gene ID
    9241 [NCBI]
  • Synonyms

    SYM1; SYNS1.

  • Research Field

    Stem Cells

Noggin Antibody (YA698) Related Classifications

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    Noggin Antibody (YA698) purchased from MedChemExpress. Usage Cited in:

    MedChemExpress Validation
     Western blot analysis of extracts from Hela (lane 2(20μg), Hela (lane 3(40μg), using Noggin Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

  • Noggin Antibody (YA698) Product Image
    1/16
  • Experimental Validation Results for Noggin Antibody (YA698)
  • Noggin Antibody (YA698) Product Image
  • Noggin Antibody (YA698) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Hela (lane 2(20μg), Hela (lane 3(40μg), using Noggin Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

  • Noggin Antibody (YA698) Product Image WB