NOG - noggin Gene

Also Known as SYM1; SYNS1; SYNS1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9241

About NOG

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,593,699-56,595,611 (from NCBI)

This gene has 1 transcript (splice variant), 240 orthologues and is associated with 11 phenotypes.

Summary

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta Superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]

NOG Products (1)

mRNA	Protein	Name
NM_005450.6	NP_005441.1	noggin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine binding	IPI IPI: Inferred from physical interaction	8752214	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19804412	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11562478	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell differentiation in hindbrain	IMP IMP: Inferred from mutant phenotype	8582276	GOA
involved in dorsal/ventral pattern formation	IDA IDA: Inferred from direct assay	7666191	GOA
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	10080184	GOA
involved in embryonic skeletal joint morphogenesis	IMP IMP: Inferred from mutant phenotype	16151340	GOA
involved in embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	10080184	GOA
involved in limb development	IMP IMP: Inferred from mutant phenotype	10080184	GOA
involved in middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10080184	GOA
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	8752214	GOA
involved in negative regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	15539560	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15539560	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	20675382	GOA
involved in negative regulation of cytokine activity	IDA IDA: Inferred from direct assay	8752214	GOA
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	20675382	GOA
involved in neural plate anterior/posterior regionalization	IMP IMP: Inferred from mutant phenotype	8582276	GOA
involved in nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	8582276	GOA
involved in regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8582276	GOA
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	17889703	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7666191	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOG Protein Structure

Noggin

0
100
200
232 a.a.

Protein Preferred Names	Protein Names
noggin	symphalangism 1 (proximal)

NOG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOG	Q13253	BMP2	Homo sapiens	P12643	SPR	19804412

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NOG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7051A	Noggin Protein, Human (CHO)	Q13253 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70542	Noggin Protein, Human (HEK293, Fc)	Q13253 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70558	Noggin Protein, Human (HEK293)	Q13253 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73322	Noggin Protein, Human (HEK293, His)	Q13253/NP_005441.1 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700143AF	Animal-Free Noggin Protein, Human (His)	Q13253 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70558G	GMP Noggin Protein, Human (HEK293, His)	Q13253 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.

NOG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80767	Noggin Antibody (YA698)	WB, ICC/IF	Human, Mouse, Rat
HY-P85580	Noggin Antibody (YA5272)	WB, ICC/IF

Related Diseases

Diseases	Alias
Tarsal-Carpal Coalition Syndrome	TCC Tarsal Carpal Coalition Syndrome Nog-Related-Symphalangism Spectrum Disorder
Brachydactyly, Type B2	Brachydactyly Type B2 BDB2 Brachydactyly B2
Stapes Ankylosis With Broad Thumbs And Toes	Stapes Ankylosis With Broad Thumb And Toes Teunissen-Cremers Syndrome Ankylosis Of Stapes, Hyperopia, Broad Thumbs, Broad First Toes, And Syndactyly Stapes Ankylosis Syndrome Without Symphalangism SABTS
Multiple Synostoses Syndrome 1	Symphalangism-Brachydactyly Syndrome SYNS1 Wl Syndrome Deafness-Symphalangism Syndrome Of Herrmann Facioaudiosymphalangism Syndrome Synostoses Multiple With Brachydactyly Synostoses, Multiple, With Brachydactyly Symphalangism Brachydactyly Syndrome Synostoses Syndrome, Multiple, 1
Symphalangism, Proximal, 1a	SYM1A Sym1 Cushing Symphalangism Hereditary Absence Of The Proximal Interphalangeal Joints Proximal Symphalangism 1a Symphalangism, Proximal 1a Symphalangism, Proximal
Multiple Synostoses Syndrome	Symphalangism-Brachydactyly Syndrome Deafness-Hermann Type Symphalangism Syndrome Facio-Audio-Symphalangism Hearing Loss-Hermann Type Symphalangism Syndrome Wl Syndrome Multiple Synostosis Syndrome
Proximal Symphalangism	Cushing'S Symphalangism Symphalangism, Proximal Hereditary Absence Of Proximal Interphalangeal Joints Strasburger-Hawkins-Eldridge Syndrome Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome Symphalangism, Proximal, 1a Symphalangism, Proximal, 1b Vessel'S Syndrome Symphalangism, Cushing Type
Ankylosis
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Brachydactyly, Type B1	Brachydactyly Type B1 Brachydactyly Type B BDB1 Brachydactyly, Type B Bdb Brachydactyly B1
Synostosis
Synostoses, Tarsal, Carpal, And Digital	Calcaneonavicular Coalition Multiple Synostosis Syndrome Synostoses, Tarsal, Carpal And Digital
Otosclerosis	Otospongiosis
Brachydactyly
Radioulnar Synostosis	Radio-Ulnar Synostosis Type 1
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Farsightedness	Hypermetropia Hyperopia Far-Sightedness Farsighted Long-Sighted Long-Sightedness
Humeroradial Synostosis	Humero-Radial Fusion Humero-Radial Synostosis Ramer Ladda Syndrome
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Acromesomelic Dysplasia 2b	Fibular Hypoplasia And Complex Brachydactyly Du Pan Syndrome AMD2B Dupans Acromesomelic Dysplasia-2b Fibular Aplasia-Complex Brachydactyly Syndrome
Sugarman Brachydactyly	Brachydactyly With Major Proximal Phalangeal Shortening Brachydactyly Of The Hands And Feet With Duplication Of The First Toes Sugarman-Hager-Kulik Syndrome Orofaciodigital Syndrome 3
Brachydactyly, Type A1, C	Brachydactyly Type A1c BDA1C Brachydactyly A1, C Brachydactyly A1c Brachydactyly Type A1 C
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Renal Fibrosis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly
Brachydactyly, Type C	Brachydactyly Type C BDC Brachydactyly Haws Type Brachydactyly, Haws Type Brachydactyly C
Telogen Effluvium
Hereditary Mixed Polyposis Syndrome	Hmps
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Dysostosis	Dysostoses
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bone Development Disease
Chromosomal Duplication Syndrome
Orofacial Cleft	Cleft, Orofacial
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99836	Cudarolimab	Inhibitor	95.00%	Phase 1
HY-P991587	SAR-446523	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164899	2A3		99.92%	Unkown
HY-163532	FLS-359	Modulator	95.41%	Unkown
HY-170452	MDM2 ligand 4	Ligand	/	Unkown
HY-175236	SF-9-2		/	Unkown
HY-184500	TNG917	Inhibitor	/	Unkown
HY-RS09410	NOG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17067	Nog Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23511	Nog Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99618	Fidasimtamab	Inhibitor	95.00%	Unkown
HY-P992381	IBI352g4a		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NOG	VGNC	VGNC:32153
Canis familiaris	NOG	VGNC	VGNC:55663
Mus musculus	NOG	MGD	MGI:104327
Rattus norvegicus	NOG	RGD	RGD:3183
Macaca mulatta	NOG	VGNC	VGNC:75364
Felis catus	NOG	VGNC	VGNC:99304
Others	NOG	NCBI