NUP153 Antibody (YA1671)

Cat. No.: HY-P81926: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

NUP153 Antibody (YA1671) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUP153.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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NUP153 Antibody (YA1671) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NUP153 Antibody (YA1671) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUP153.

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 154 kDa;

Observed band size: 154 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P49790

Gene ID

9972 [NCBI]

Immunogen

A synthesized peptide derived from human Nup153 aa55-96.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:50-1:100

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC); (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro); (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro)

Subcellular Localization：Nucleus; Nucleus membrane; Nucleus, nuclear pore complex

Isoforms & Post-Translational Modification：P49790 has 3 isomers: P49790-1: 153938 Da (predicted); P49790-2: 149396 Da (predicted); P49790-3: 157338 Da (predicted).
Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity);Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation;O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status

Subunit：Part of the nuclear pore complex (NPC) (PubMed:15229283). Interacts with TPR (via coiled coil region); the interaction is direct and provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex (NPC) (PubMed:12802065, PubMed:20133940). Interacts with HIKESHI (PubMed:22541429). Interacts with SENP2. Interacts with XPO5 (PubMed:11777942). Interacts with RAN; the interaction occurs in a GTP- and GDP-independent manner (By similarity). Interacts with MCM3AP isoform GANP; this interaction is required for GANP localization at the nuclear pore complex (PubMed:20005110, PubMed:23652018). Interacts with MAPK1 (PubMed:22253824)

Database

Entrez Gene: 9972 Human

SwissProt: P49790 Human

OMIM: 603948 Human

Research Field

Tags & Cell Markers

Synonyms

HNUP153; Nup153

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

NUP153 Antibody (YA1671) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NUP153 Antibody (YA1671)

NUP153 Antibody (YA1671) Featured Recommendations:

Product Detail

Background

Documentation

NUP153 Antibody (YA1671) Related Classifications

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