PD-L2 Antibody (YA1348)
(Synonyms: PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273)PD-L2 Antibody (YA1348) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:50-1:100 | 1:10000 |
Product Details
PD-L2 Antibody (YA1348) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PD-L2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50-70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Recombinant human PDL2 protein
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PD-L2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production
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Subcellular Localization
Secreted; Endomembrane system; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is highly expressed in the heart, placenta, pancreas, lungs, and liver, and lowly expressed in the spleen, lymph nodes, and thymus.
Induction:Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4 -
Isoforms & Post-Translational Modification
Q9BQ51 has 3 isomers: Q9BQ51-1: 30957 Da (predicted); Q9BQ51-2: 20867 Da (predicted); Q9BQ51-3: 20745 Da (predicted).
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Subunit
Interacts with PDCD1
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SwissProt ID
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Synonyms
PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273
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Research Field
Immunology
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