PDCD1LG2 - programmed cell death 1 ligand 2 Gene

Also Known as B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80380

About PDCD1LG2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,510,531-5,571,282 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues, 12 paralogues and is associated with 52 phenotypes. Broad expression in spleen (RPKM 7.3), lymph node (RPKM 5.3) and 21 other tissues.

Summary

Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2022]

PDCD1LG2 Products (1)

mRNA	Protein	Name
NM_025239.4	NP_079515.2	programmed cell death 1 ligand 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20587542	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	12538684	GOA
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	12538684	GOA
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	12538684	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD1LG2 Protein Structure

Ig_2

Ig_3

0
100
200
273 a.a.

Protein Preferred Names	Protein Names
programmed cell death 1 ligand 2	B7 dendritic cell molecule

PDCD1LG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDCD1LG2	Q9BQ51	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	PDCD1LG2	Q9BQ51	TAS2R10	Homo sapiens	Q9NYW0	Validated Y2H	32296183
Intra	PDCD1LG2	Q9BQ51	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	PDCD1LG2	Q9BQ51	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	PDCD1LG2	Q9BQ51	PDCD1	Homo sapiens	Q15116	SPR	20587542
Intra	PDCD1LG2	Q9BQ51	PDCD1	Homo sapiens	Q15116	NMR	23417675
Intra	PDCD1LG2	Q9BQ51	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	PDCD1LG2	Q9BQ51	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD1LG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7399	PD-L2 Protein, Human (HEK293, Fc)	Q9BQ51-1 (L20-P219)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70734	PD-L2 Protein, Human (HEK293, mFc)	Q9BQ51-1 (L20-P219)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72407	PD-L2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9BQ51-1 (L20-P219)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72492	PD-L2 Protein, Human (HEK293, His)	Q9BQ51-1 (L20-P219)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77528	PD-L2 Protein, Human (Biotinylated, HEK293, His)	Q9BQ51-1 (L20-P219)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78505	PD-L2 Protein, Human (HEK293, His-Avi)	Q9BQ51-1 (L20-T220)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78821	PD-L2 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9BQ51-1 (L20-P219)	≥ 95%, as determined by reducing SDS-PAGE.

PDCD1LG2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81603	PD-L2 Antibody (YA1348)	FC, ELISA	Human
HY-P81839	PD-L2 Antibody (YA1584)	WB	Human, Rat
HY-P81839A	PD-L2 Antibody (YA3391)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P81839AA	PD-L2 Antibody (YA3391)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Autoimmune Cardiomyopathy
Testicular Lymphoma	Malignant Lymphoma Of Testis Lymphoma Of The Testis
Primary Mediastinal B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Gray Zone Lymphoma	B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Gastroesophageal Junction Adenocarcinoma	Adenocarcinoma Of Cardioesophageal Junction Adenocarcinoma Of Gastroesophageal Junction Adenocarcinoma Of The Gastroesophageal Junction
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Type 1 Diabetes Mellitus 21	Diabetes Mellitus, Insulin-Dependent, 21 Iddm21 T1D21 Insulin-Dependent Diabetes Mellitus 21
Selective Igg Deficiency Disease	Igg Deficiency Immunoglobin G Subclass Deficiency Selective Deficiency Of Igg Selective Igg Immunodeficiency Selective Immunoglobulin G Deficiency Selective Immunoglobulin G Subclass Deficiency
Gastroesophageal Adenocarcinoma	Gastric And Esophageal Adenocarcinoma Gastro-Esophageal Adenocarcinoma
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Necrotizing Gastritis
Central Nervous System Hematologic Cancer	Cns Hematopoietic Tumor Hematopoietic Neoplasm Of Central Nervous System Central Nervous System Hematopoietic Neoplasm
Central Nervous System Lymphoma	Microglioma Primary Cns Lymphoma Cns Lymphoma Primary Central Nervous System Lymphoma
Penis Carcinoma In Situ	Carcinoma In Situ Of Penis Bowen'S Disease Of Penis Grade Iii Squamous Intraepithelial Lesion Of Penis Penile Intraepithelial Neoplasia Grade Iii Queyrat'S Erythroplasia Erythroplasia Of Queyrat Pin - [Penile Intraepithelial Neoplasia]
Uterine Body Mixed Cancer	Malignant Mixed Tumor Of Corpus Uteri Malignant Mixed Tumor, Not Otherwise Specified
Endocervical Carcinoma	Carcinoma Of Endocervix Carcinoma Of The Endocervix
Refractory Plasma Cell Neoplasm
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Head And Neck Cancer	Head And Neck Neoplasm Head And Neck Tumours Head/Neck Neoplasm Tumor Of Head And Neck Head And Neck Neoplasms Hnc Cancer, Head/Neck

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10190	PDCD1LG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18210	Pdcd1lg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24687	Pdcd1lg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDCD1LG2	VGNC	VGNC:56980
Rattus norvegicus	PDCD1LG2	RGD	RGD:1306403
Canis familiaris	PDCD1LG2	VGNC	VGNC:44336
Mus musculus	PDCD1LG2	MGD	MGI:1930125
Felis catus	PDCD1LG2	VGNC	VGNC:64078
Macaca mulatta	PDCD1LG2	VGNC	VGNC:75645
Others	PDCD1LG2	NCBI