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  5. PIST Antibody (YA1647)

PIST Antibody (YA1647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIST.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

PIST Antibody (YA1647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIST.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 51 kDa;
Observed band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human PIST aa1-50/462.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
FC
FC: Flow Cytometry
1:50-1:100
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915)
Subcellular Localization：Cytoplasm; Golgi apparatus membrane; Peripheral membrane protein; Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Synapse; Postsynaptic density; Cell projection, dendrite
Expression：
Tissue_specificity:Ubiquitously expressed
Isoforms & Post-Translational Modification：Q9HD26 has 3 isomers: Q9HD26-1: 50520 Da (predicted); Q9HD26-2: 49721 Da (predicted); Q9HD26-3: 35130 Da (predicted).
Subunit：Homooligomer (By similarity). Interacts with FZD5 (By similarity). Interacts with FZD8 (PubMed:16882988). Interacts with GRID2 and BECN1 (By similarity). Interacts with CSPG5 (By similarity). Interacts with CLCN3 (By similarity). Interacts with STX6 (PubMed:11384996). Interacts with CFTR (PubMed:11707463). Interacts with ASIC3 (PubMed:15317815). Interacts with GOLGA3 (PubMed:15951434). Interacts with NLGN1 (PubMed:16882988). Interacts with RHOQ (PubMed:15546864). Interacts with MARCHF2; the interaction leads to CFTR ubiquitination and degradation (PubMed:23818989). Interacts with ADRB1 (PubMed:15358775). May interact with CACNG2 (By similarity). Interacts with CCDC62 (By similarity)
Database

Entrez Gene: 57120 Human ;

SwissProt: Q9HD26 Human ; Q3TAF1 Mouse ; Q8BH60 Mouse ;

OMIM: 606845 Human

Research Field

Tags & Cell Markers
Synonyms
GOPC; CAL; CFTR-associated ligand; GOPC1; FIG; PIST
Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
References

PIST Antibody (YA1647) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PIST Antibody (YA1647)
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