PIST Antibody (YA1647)
(Synonyms: GOPC; CAL; CFTR-associated ligand; GOPC1; FIG; PIST)
Based on 1 Customer Validation
PIST Antibody (YA1647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIST.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC, IP
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Reactivity :
Human, Mouse
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 | 1:50-1:100 | 1:50 |
Product Details
PIST Antibody (YA1647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIST.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Entrez Gene: 57120 Human ;
SwissProt: Q9HD26 Human ; Q3TAF1 Mouse ; Q8BH60 Mouse ;
OMIM: 606845 Human
A synthesized peptide derived from human PIST aa1-50/462.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PIST plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes[1][2][3][4].
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Subcellular Localization
Cytoplasm; Golgi apparatus membrane; Peripheral membrane protein; Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Synapse; Postsynaptic density; Cell projection, dendrite
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Expression
Tissue_specificity:Ubiquitously expressed -
Isoforms & Post-Translational Modification
Q9HD26 has 3 isomers: Q9HD26-1: 50520 Da (predicted); Q9HD26-2: 49721 Da (predicted); Q9HD26-3: 35130 Da (predicted).
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Subunit
Homooligomer (By similarity). Interacts with FZD5 (By similarity). Interacts with FZD8 (PubMed:16882988). Interacts with GRID2 and BECN1 (By similarity). Interacts with CSPG5 (By similarity). Interacts with CLCN3 (By similarity). Interacts with STX6 (PubMed:11384996). Interacts with CFTR (PubMed:11707463). Interacts with ASIC3 (PubMed:15317815). Interacts with GOLGA3 (PubMed:15951434). Interacts with NLGN1 (PubMed:16882988). Interacts with RHOQ (PubMed:15546864). Interacts with MARCHF2; the interaction leads to CFTR ubiquitination and degradation (PubMed:23818989). Interacts with ADRB1 (PubMed:15358775). May interact with CACNG2 (By similarity). Interacts with CCDC62 (By similarity)
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SwissProt ID
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Synonyms
GOPC; CAL; CFTR-associated ligand; GOPC1; FIG; PIST
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Research Field
Tags & Cell Markers
Documentation
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