GOPC - golgi associated PDZ and coiled-coil motif containing Gene

Homo sapiens

Also known as CAL; FIG; PIST; GOPC1; dJ94G16.2

Gene ID: 57120 | Gene type: protein coding

About GOPC

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,560,269-117,602,511 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and is associated with 55 phenotypes. Ubiquitous expression in thyroid (RPKM 17.5), endometrium (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GOPC Products(2)

mRNA	Protein	Name
NM_001017408.3	NP_001017408.1	Golgi-associated PDZ and coiled-coil motif-containing protein isoform b
NM_020399.4	NP_065132.1	Golgi-associated PDZ and coiled-coil motif-containing protein isoform a

GOPC Protein Structure

PDZ

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

Golgi-associated PDZ and coiled-coil motif-containing protein

CFTR-associated ligand

Recombinant GOPC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73708	PIST Protein, Human (His)	Q9HD26 (I286-Y462)	≥95%

Related Diseases

Diseases

Alias

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Acute Laryngitis

Acute Laryngitis Nos	Laryngeal Inflammation
Laryngitis Nos	Larynx Inflammation

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Childhood Angiosarcoma

Paediatric Angiosarcoma	Paediatric Hemangiosarcoma
Pediatric Angiosarcoma	Pediatric Hemangiosarcoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Neonatal Candidiasis

Neonatal Candida Infection	Neonatal Monilia Infection
Neonatal Moniliasis

Sclerosing Hepatic Carcinoma

Sclerosing Hepatocellular Carcinoma

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05599	GOPC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GOPC	VGNC	VGNC:97446
Bos taurus	GOPC	VGNC	VGNC:53793
Mus musculus	GOPC	MGD	MGI:2149946
Rattus norvegicus	GOPC	RGD	RGD:1309512
Canis familiaris	GOPC	VGNC	VGNC:49713
Others	GOPC	NCBI