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GOPC - golgi associated PDZ and coiled-coil motif containing Gene

Also Known as CAL; FIG; PIST; GOPC1; dJ94G16.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57120

About GOPC

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,560,269-117,602,511 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and is associated with 55 phenotypes. Ubiquitous expression in thyroid (RPKM 17.5), endometrium (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind Other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GOPC Products (2)

mRNA	Protein	Name
NM_001017408.3	NP_001017408.1	Golgi-associated PDZ and coiled-coil motif-containing protein isoform b
NM_020399.4	NP_065132.1	Golgi-associated PDZ and coiled-coil motif-containing protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11707463	GOA
enables molecular sequestering activity	IMP IMP: Inferred from mutant phenotype	11707463	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11384996	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	11707463	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of anion channel activity	IMP IMP: Inferred from mutant phenotype	11707463	GOA
involved in negative regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	11707463	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11384996	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11707463	GOA
located in membrane	IDA IDA: Inferred from direct assay	11707463	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18468998	GOA
located in trans-Golgi network transport vesicle	IDA IDA: Inferred from direct assay	11707463	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOPC Protein Structure

PDZ

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
Golgi-associated PDZ and coiled-coil motif-containing protein	CFTR-associated ligand

GOPC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GOPC	Q9HD26	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	GOPC	Q9HD26	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	GOPC	Q9HD26	C17orf67	Homo sapiens	Q0P5P2	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	PWWP3A	Homo sapiens	Q2TAK8-2	Validated Y2H	25416956
Intra	GOPC	Q9HD26	PWWP3A	Homo sapiens	Q2TAK8-2	Y2H Array	25416956
Intra	GOPC	Q9HD26	ZNF509	Homo sapiens	Q32MK9	Validated Y2H	25416956
Intra	GOPC	Q9HD26	ZNF509	Homo sapiens	Q32MK9	Y2H Array	25416956
Intra	GOPC	Q9HD26	LCLAT1	Homo sapiens	Q6UWP7	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	PID1	Homo sapiens	Q7Z2X4	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	ZNF564	Homo sapiens	Q8TBZ8	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	ZNF564	Homo sapiens	Q8TBZ8	Validated Y2H	25416956
Intra	GOPC	Q9HD26	ZNF564	Homo sapiens	Q8TBZ8	Y2H Array	25416956
Intra	GOPC	Q9HD26	MORN4	Homo sapiens	Q8WVZ3	Validated Y2H	25416956
Intra	GOPC	Q9HD26	RNF220	Homo sapiens	Q9BWG1	Validated Y2H	25416956
Intra	GOPC	Q9HD26	RNF220	Homo sapiens	Q9BWG1	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	AKIRIN1	Homo sapiens	Q9H9L7	Validated Y2H	25416956
Intra	GOPC	Q9HD26	HEL-S-42	Homo sapiens	V9HWD0	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	HEL-S-42	Homo sapiens	V9HWD0	Validated Y2H	25416956
Intra	GOPC	Q9HD26	VTN	Homo sapiens	P04004	Validated Y2H	25416956
Intra	GOPC	Q9HD26	VTN	Homo sapiens	P04004	Y2H Array	25416956
Intra	GOPC	Q9HD26	VTN	Homo sapiens	P04004	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	PARK7	Homo sapiens	Q99497	Validated Y2H	25416956
Intra	GOPC	Q9HD26	SSNA1	Homo sapiens	O43805	Anti Tag CoIP	33961781
Intra	GOPC	Q9HD26	SSNA1	Homo sapiens	O43805	Validated Y2H	25416956
Intra	GOPC	Q9HD26	DPYD	Homo sapiens	Q12882	Y2H Array	25416956
Intra	GOPC	Q9HD26	DPYD	Homo sapiens	Q12882	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	ZBTB49	Homo sapiens	Q6ZSB9	Y2H Array	29892012
Intra	GOPC	Q9HD26	ZBTB49	Homo sapiens	Q6ZSB9	Y2H Array	31515488
Intra	GOPC	Q9HD26	ZBTB49	Homo sapiens	Q6ZSB9	Validated Y2H	25416956
Intra	GOPC	Q9HD26	HCK	Homo sapiens	P08631	Validated Y2H	25416956
Intra	GOPC	Q9HD26	HCK	Homo sapiens	P08631	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	HCK	Homo sapiens	P08631	Y2H Array	25416956
Intra	GOPC	Q9HD26	CFTR	Homo sapiens	P13569	Anti Tag CoIP	28360110
Intra	GOPC	Q9HD26	CFTR	Homo sapiens	P13569	Pull Down	12471024
Intra	GOPC	Q9HD26	FOSL2	Homo sapiens	P15408	Y2H Array	25416956
Intra	GOPC	Q9HD26	FOSL2	Homo sapiens	P15408	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	FOSL2	Homo sapiens	P15408	Validated Y2H	25416956
Intra	GOPC	Q9HD26	MYOCD	Homo sapiens	Q8IZQ8	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	ZSCAN1	Homo sapiens	Q8NBB4	Y2H Array	25416956
Intra	GOPC	Q9HD26	SLC25A18	Homo sapiens	Q9H1K4	Validated Y2H	25416956
Intra	GOPC	Q9HD26	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	25416956
Intra	GOPC	Q9HD26	ZNF587	Homo sapiens	Q96SQ5	Y2H Array	25416956
Intra	GOPC	Q9HD26	SEMA4G	Homo sapiens	Q9NTN9	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	GOPC	Q9HD26	RNF183	Homo sapiens	Q96D59	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	25416956
Intra	GOPC	Q9HD26	BATF	Homo sapiens	Q16520	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	BATF	Homo sapiens	Q16520	Validated Y2H	25416956
Intra	GOPC	Q9HD26	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	GOPC	Q9HD26	SPATA8	Homo sapiens	Q6RVD6	Y2H Array	25416956
Intra	GOPC	Q9HD26	SPATA8	Homo sapiens	Q6RVD6	Y2H Prey Pooling	25416956
Intra	GOPC	Q9HD26	MYLK	Homo sapiens	Q15746	Y2H Array	25416956
Intra	GOPC	Q9HD26	STARD3	Homo sapiens	Q14849	Validated Y2H	25416956
Intra	GOPC	Q9HD26	STARD3	Homo sapiens	Q14849	Y2H Prey Pooling	25416956
Cross	GOPC	Q9HD26	mGluR1a	Rattus norvegicus	Q9R0W0	IF	19027007
Cross	GOPC	Q9HD26	mGluR1a	Rattus norvegicus	Q9R0W0	Pull Down	19027007

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GOPC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73708	PIST Protein, Human (His)	Q9HD26-1 (I286-Y462)	≥ 95%, as determined by reducing SDS-PAGE.

GOPC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81902	PIST Antibody (YA1647)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse

Related Diseases

Diseases	Alias
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Acute Laryngitis	Acute Laryngitis Nos Laryngeal Inflammation Laryngitis Nos Larynx Inflammation
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Childhood Angiosarcoma	Paediatric Angiosarcoma Paediatric Hemangiosarcoma Pediatric Angiosarcoma Pediatric Hemangiosarcoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6
Neonatal Candidiasis	Neonatal Candida Infection Neonatal Monilia Infection Neonatal Moniliasis
Sclerosing Hepatic Carcinoma	Sclerosing Hepatocellular Carcinoma
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05599	GOPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20279	Gopc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26787	Gopc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GOPC	VGNC	VGNC:97446
Bos taurus	GOPC	VGNC	VGNC:53793
Mus musculus	GOPC	MGD	MGI:2149946
Rattus norvegicus	GOPC	RGD	RGD:1309512
Canis familiaris	GOPC	VGNC	VGNC:49713
Others	GOPC	NCBI