SLC25A18 - solute carrier family 25 member 18 Gene

Homo sapiens

Also known as GC2

Gene ID: 83733 | Gene type: protein coding

About SLC25A18

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,563,498-17,590,995 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 49 paralogues. Biased expression in brain (RPKM 15.7), liver (RPKM 8.1) and 2 other tissues.

Summary

Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC25A18 Products(2)

mRNA	Protein	Name
NM_001303484.2	NP_001290413.1	mitochondrial glutamate carrier 2
NM_031481.3	NP_113669.1	mitochondrial glutamate carrier 2

SLC25A18 Protein Structure

Mito_carr

0
100
200
315 a.a.

Protein Preferred Names

Protein Names

mitochondrial glutamate carrier 2

glutamate/H(+) symporter 2

Related Diseases

Diseases

Alias

Leber Congenital Amaurosis 12

LCA12

Leber Congenital Amaurosis, Type 12

Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral	Agc1 Deficiency
Epileptic Encephalopathy, Early Infantile, 39	DEE39
Eiee39	Aspartate-Glutamate Carrier 1 Deficiency
Epileptic Encephalopathy With Global Cerebral Demyelination	Developmental And Epileptic Encephalopathy, 39
Early Infantile Epileptic Encephalopathy 39	Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency
Global Cerebral Hypomyelination	Hereditary Central Nervous System Demyelinating Diseases

Phencyclidine Abuse

Pcp Abuse

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13098	SLC25A18 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC25A18	MGD	MGI:1919053
Rattus norvegicus	SLC25A18	RGD	RGD:1590470
Canis familiaris	SLC25A18	VGNC	VGNC:46297
Felis catus	SLC25A18	VGNC	VGNC:65260
Macaca mulatta	SLC25A18	VGNC	VGNC:77434
Others	SLC25A18	NCBI

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