SEMA4G - semaphorin 4G Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57715

About SEMA4G

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,969,504-100,985,616 (from NCBI)

This gene has 10 transcripts (splice variants), 266 orthologues and 19 paralogues. Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues.

Summary

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

SEMA4G Products (3)

mRNA	Protein	Name
NM_001203244.1	NP_001190173.1	semaphorin-4G isoform 2 precursor
NM_001393925.1	NP_001380854.1	semaphorin-4G isoform 3 precursor
NM_017893.4	NP_060363.2	semaphorin-4G isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA4G Protein Structure

Sema

PSI

0
200
400
600
800
838 a.a.

Protein Preferred Names	Protein Names
semaphorin-4G	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

SEMA4G Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEMA4G	Q9NTN9	GOPC	Homo sapiens	Q9HD26	Validated Y2H	25416956
Intra	SEMA4G	Q9NTN9	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
Intra	SEMA4G	Q9NTN9	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	SEMA4G	Q9NTN9	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	SEMA4G	Q9NTN9	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SEMA4G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71286	Semaphorin-4G/SEMA4G Protein, Human (HEK293, His)	Q9NTN9-2 (V18-L680)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Diffuse Glomerulonephritis	Glomerulonephritis Diffuse
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12662	SEMA4G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20595	Sema4g Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27103	Sema4g Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEMA4G	VGNC	VGNC:64996
Macaca mulatta	SEMA4G	VGNC	VGNC:77168
Bos taurus	SEMA4G	VGNC	VGNC:34438
Mus musculus	SEMA4G	MGD	MGI:1347047
Rattus norvegicus	SEMA4G	RGD	RGD:1310436
Canis familiaris	SEMA4G	VGNC	VGNC:45998
Others	SEMA4G	NCBI