2. Gene
  3. SEMA4G - semaphorin 4G Gene

SEMA4G - semaphorin 4G Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57715 | Gene type: protein coding

About SEMA4G

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,969,504-100,985,616 (from NCBI)

This gene has 10 transcripts (splice variants), 266 orthologues and 19 paralogues. Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues.

Summary

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

SEMA4G Products(3)

mRNA Protein Name
NM_001203244.1 NP_001190173.1 semaphorin-4G isoform 2 precursor
NM_001393925.1 NP_001380854.1 semaphorin-4G isoform 3 precursor
NM_017893.4 NP_060363.2 semaphorin-4G isoform 1 precursor

SEMA4G Protein Structure

Sema

Sema: Sema domain (56 - 486)

PSI

PSI: Plexin repeat (507 - 539)

  • 0
  • 200
  • 400
  • 600
  • 838 a.a.
Protein Preferred Names Protein Names

semaphorin-4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Recombinant SEMA4G Proteins

Cat. No. Product Name Accession Purity
HY-P71286 Semaphorin-4G/SEMA4G Protein, Human (HEK293, His) Q9NTN9-2 (V18-L680) ≥95%

Related Diseases

Diseases Alias
Diffuse Glomerulonephritis

Glomerulonephritis Diffuse
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12662 SEMA4G Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SEMA4G VGNC VGNC:64996
Macaca mulatta SEMA4G VGNC VGNC:77168
Bos taurus SEMA4G VGNC VGNC:34438
Mus musculus SEMA4G MGD MGI:1347047
Rattus norvegicus SEMA4G RGD RGD:1310436
Canis familiaris SEMA4G VGNC VGNC:45998
Others SEMA4G NCBI