Antimalarial agent 33

製品番号: HY-155354 純度: 99.13%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC₅₀ of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T_1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Antimalarial agent 33 構造式

CAS 番号 : 3053680-00-2

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 231	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 231	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$210	在庫あり	Estimated Time of Arrival: December 31
10 mg	$335	在庫あり	Estimated Time of Arrival: December 31
25 mg	$675	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1085	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1740	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	CC₅₀	>100 μM Compound: 5g	Cytotoxicity against Cynomolgous monkey hepatocytes harboring Simian virus assessed as reduction in cell viability administered for 3 hrs followed by replacement with fresh medium containing compound for every 24 hrs by DAPI staining based analysis Cytotoxicity against Cynomolgous monkey hepatocytes harboring Simian virus assessed as reduction in cell viability administered for 3 hrs followed by replacement with fresh medium containing compound for every 24 hrs by DAPI staining based analysis	[PMID: 37857143]
HepG2	CC₅₀	14 μM Compound: 5g	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37857143]

分子量

311.40

分子式

C₁₇H₁₇N₃OS

CAS 番号

3053680-00-2

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(C2=CC(N=C(NC3CCC3)NC4=O)=C4S2)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 5 mg/mL (16.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2113 mL	16.0565 mL	32.1130 mL
5 mM	0.6423 mL	3.2113 mL	6.4226 mL
10 mM	0.3211 mL	1.6057 mL	3.2113 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.13%

Select Batch:

データシート (267 KB) SDS (251 KB)

COA (245 KB) HNMR (230 KB) LCMS (104 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Prisca Lagardère, et al. Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability. Eur J Med Chem. 2023 Dec 5:261:115873. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2113 mL	16.0565 mL	32.1130 mL	80.2826 mL
	5 mM	0.6423 mL	3.2113 mL	6.4226 mL	16.0565 mL
	10 mM	0.3211 mL	1.6057 mL	3.2113 mL	8.0283 mL
	15 mM	0.2141 mL	1.0704 mL	2.1409 mL	5.3522 mL