Antiproliferative agent-3
Antiproliferative agent-3 is an antiproliferative agent. Antiproliferative agent-3 exhibits anticancer activity against a variety of cancers, including estrogen receptor-positive breast cancer. Antiproliferative agent-3 shows no toxicity to wild-type zebrafish embryos. Antiproliferative agent-3 can be used in the research of chronic myeloid leukemia, promyelocytic leukemia, Burkitt's lymphoma, estrogen receptor-positive mammary adenocarcinoma, cervical cancer, and lung cancer.
For research use only. We do not sell to patients.
- Formula: C11H12N2O5S
- Molecular Weight:284.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antiproliferative agent-3 (Compound 4) (72 h) potently inhibits the growth of multiple human tumour cell lines, with exceptional activity against MCF-7 cells (IC50 = 0.00019 μM), and shows no toxicity to MRC-5 normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type[1]
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Dosage:1 µM, 2.5 µM, 5 µM, 10 µM, 25 µM, 50 µM, 100 µM, 125 µM
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Administration:in embryo water; continuous; 6 hpf to 120 hpf
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Result:Allowed all embryos to survive at all tested concentrations up to 125 µM, with no teratogenic malformations.
Resulted in an embryo heartbeat rate of 154 beats per minute at 125 µM, compared to 158 beats per minute in the control group, with no pericardial edema observed.
Determined a lethal concentration 50 (LC50) to be >125 µM.
Chemical Information
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Molecular Weight 284.29
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Formula C11H12N2O5S
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SMILES
NC(C1=CSC(C[C@H]2O[C@@H]3CC(O[C@@H]3[C@H]2O)=O)=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-3 Related Classifications
HY-145866 Related Classifications
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Keywords
- Antiproliferative agent-3
- Antiproliferative agent3
- Antiproliferative agent 3
- Drug Intermediate
- T cell leukaemia
- lung carcinoma
- oestrogen receptor positive breast adenocarcinoma
- chronic myeloid leukaemia
- promyelocytic leukaemia
- estrogen receptor positive breast adenocarcinoma cells
- MCF-7 cells
- cervix carcinoma
- zebrafish models
- Burkitt’s lymphoma
- Inhibitor
- inhibitor
- inhibit