121077-11-0
121077-11-0
Chemical Structure
KU-2285
- CAS. Nr.: 121077-11-0
- Formula:C8H10F2N4O4
- Molecular Weight:264.19
IUPAC Name: 2,2-difluoro-N-(2-hydroxyethyl)-3-(2-nitro-1H-imidazol-1-yl)propanamide
InChIKey: VOXUFOPZGRTSJY-UHFFFAOYSA-N
SMILES: O=C(NCCO)C(F)(F)CN1C=CN=C1[N+]([O-])=O
Biological Activity: KU-2285 is an orally active fluorinated 2-nitroimidazole hypoxic cell radiosensitizer. KU-2285 has higher lipophilicity, superior sensitizing activity to Etanidazole (HY-116972), and lower neurotoxicity. KU-2285 can be used in research related to tumor diagnosis[1][2].
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KU-2285 | KU-2285 is an orally active fluorinated 2-nitroimidazole hypoxic cell radiosensitizer. KU-2285 has higher lipophilicity, superior sensitizing activity to Etanidazole (HY-116972), and lower neurotoxicity. KU-2285 can be used in research related to tumor diagnosis. | |||||||||||||||||||||
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References
- [1]. Sasai K, et al. A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer. Int J Radiat Oncol Biol Phys. 1991 Jun;20(6):1249-54. [Content Brief]
- [2]. Shibamoto Y, et al. A phase I study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy. Radiother Oncol. 1996 Jul;40(1):55-8. [Content Brief]
