126455-04-7
Chemical Structure
AL-1
- CAS. Nr.: 126455-04-7
- Formula:C19H22O5
- Molecular Weight:330.37
IUPAC Name: (1R,2R,5S,5'S,E)-4-(hexa-2,4-diyn-1-ylidene)tetrahydro-3,6-dioxaspiro[bicyclo[3.1.0]hexane-2,2'-pyran]-5'-yl 3-methylbutanoate
InChIKey: IZOBIZVXEKNCNN-ZNQIEUMMSA-N
SMILES: CC#CC#C/C=C1[C@]2([H])[C@](O2)([H])[C@@]3(CC[C@@H](CO3)OC(CC(C)C)=O)O\1
Biological Activity: AL-1 is a potent O2- generation inhibitor (IC50 = 7.6 μM) through the inhibition of leukocytic NADPH oxidase. AL-1 inhibits 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced H2O2 production. AL-1 reduces tumor incidence in ICR mouse skin. AL-1 can be used for research on oxidative stress-related diseases including cancer[1].
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AL-1 | AL-1 is a potent O2- generation inhibitor (IC50 = 7.6 μM) through the inhibition of leukocytic NADPH oxidase. AL-1 inhibits 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced H2O2 production. AL-1 reduces tumor incidence in ICR mouse skin. AL-1 can be used for research on oxidative stress-related diseases including cancer. | |||||||||||||||||||||
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