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Art. -Nr.: HY-162416

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CDK7-IN-27

CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with K_i of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase.

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CAS. Nr.: 3025006-89-4
Formel: C₂₆H₃₇N₇O₂
Molecular Weight:479.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

CDK7-IN-27 Chemical Structure

CAS. Nr.: 3025006-89-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with K_i of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase^[1].

IC₅₀ & Target

CDK7

3 nM (IC₅₀)

CDK2

19.4 nM (IC₅₀)

Alle CDK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-453	EC₅₀	1.49 μM Compound: 37	Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability incubated for 5 days by CCK-8 assay Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability incubated for 5 days by CCK-8 assay	[PMID: 38586950]

In Vitro

CDK7-IN-27 (0.04-10 μM, 5 days) inhibits proliferations of MDA-MB-453 cells with EC₅₀ of 1.49 μM^[1].
CDK7_IN-27 (1 μM, 24 h) exhibits good metabolic stability in liver microsomes in mouse and human , with a half-time of 38.5 min and 34.1 min^[1].
CDK7_IN-27 (0-1 μM, 24 h) suppresses the phosphorylation of retinoblastoma (Rb) protein through CDK7 inhibition, and thus arrests the cell cycle at G0/G1 phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-453
Concentration:

0-1 μM
Incubation Time:

24 h
Result:

Inhibited phosphorylation of Rb protein at Ser780, 807/811, and Thr826.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-453
Concentration:

0.04-10 μM
Incubation Time:

5 days
Result:

Suppressed the cancer cell proliferation.

Chemical Information

CAS. Nr. 3025006-89-4
Molecular Weight 479.62
Formel C₂₆H₃₇N₇O₂
SMILES

CC(C1=C2N=C3N=C(N2N=C1)NCC4=CC=CC=C4OC[C@H](CCCC5(CN3)CCNCC5)O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Niu P, et al., Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors. J Med Chem. 2024 Apr 8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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CDK7-IN-27

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CDK7-IN-27 Related Classifications

HY-162416 Related Classifications