MYL6B - myosin light chain 6B Gene

Also Known as MLC1SA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140465

About MYL6B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,152,587-56,157,982 (from NCBI)

This gene has 15 transcripts (splice variants), 254 orthologues and 4 paralogues. Broad expression in testis (RPKM 60.9), prostate (RPKM 37.4) and 24 other tissues.

Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a Myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

MYL6B Products (2)

mRNA Protein Name
NM_001199629.2 NP_001186558.1 myosin light chain 6B
NM_002475.5 NP_002466.1 myosin light chain 6B

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
15510214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL6B Protein Structure

EF-hand_6

EF-hand_6: EF-hand domain (68 - 97)

EF-hand_7

EF-hand_7: EF-hand domain pair (150 - 203)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

myosin light chain 6B

  • myosin alkali light chain 1 slow a

MYL6B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
MYL6B P14649 SPA17 Homo sapiens Q15506
Validated Y2H
32296183
Intra
MYL6B P14649 SPA17 Homo sapiens Q15506
Y2H Array
32296183
Intra
MYL6B P14649 SPA17 Homo sapiens Q15506
Y2H Prey Pooling
32296183
Cross
MYL6B P14649 MYO5A Gallus gallus Q02440
X-Ray Diffraction
15510214
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Scapuloperoneal Syndrome, Neurogenic, Kaeser Type

  • KAESER SYNDROME

  • Stark-Kaeser Syndrome

  • Neurogenic Scapuloperoneal Syndrome Kaeser Type

  • Neurogenic Scapuloperoneal Syndrome, Kaeser Type

  • Scapuloperoneal Syndrome, Neurogenic Type, Of Kaeser

  • SCPNK

  • Scapuloperoneal Syndrome Type Kaeser
Myopathy, Centronuclear, 2

  • Myopathy, Centronuclear, Autosomal Recessive

  • Autosomal Recessive Centronuclear Myopathy

  • CNM2

  • Centronuclear Myopathy 2

  • Ar-Cnm

  • Myotubular Myopathy, Autosomal Recessive

  • Autosomal Recessive Myotubular Myopathy

  • Centronuclear Myopathy Autosomal Recessive

  • Myopathy, Centronuclear, Type 2
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08919 MYL6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MYL6B VGNC VGNC:43546
Mus musculus MYL6B MGD MGI:1917789
Bos taurus MYL6B VGNC VGNC:31803
Macaca mulatta MYL6B VGNC VGNC:75043
Rattus norvegicus MYL6B RGD RGD:1560334
Felis catus MYL6B VGNC VGNC:63678
Others MYL6B NCBI