SIK1 - salt inducible kinase 1 Gene

Also Known as MSK; SIK; DEE30; SIK-1; SIK1B; SNF1LK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 150094

About SIK1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:43,414,483-43,427,131 (from NCBI)

This gene has 6 transcripts (splice variants), 236 orthologues, 17 paralogues and is associated with 5 phenotypes. Ubiquitous expression in adrenal (RPKM 28.1), liver (RPKM 25.6) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]

SIK1 Products (2)

mRNA	Protein	Name
NM_173354.5	NP_775490.2	serine/threonine-protein kinase SIK1
XM_011529474.3	XP_011527776.1	serine/threonine-protein kinase SIK1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	18348280	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16306228	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18348280	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14976552	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14976552	GOA
involved in positive regulation of anoikis	IMP IMP: Inferred from mutant phenotype	19622832	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18348280	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14976552	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16306228	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16306228	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIK1 Protein Structure

Pkinase

0
200
400
600
783 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase SIK1	Probable serine/threonine-protein kinase SIK1B SNF1-like kinase Salt-inducible kinase 1B myocardial SNF1-like kinase salt-inducible protein kinase 1 serine/threonine-protein kinase SNF1-like kinase 1 serine/threonine-protein kinase SNF1LK

SIK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SIK1	P57059	YWHAZ	Homo sapiens	P63104	TAP	16306228
Intra	SIK1	P57059	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
Intra	SIK1	P57059	YWHAE	Homo sapiens	P62258	TAP	16306228
Intra	SIK1	P57059	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	SIK1	P57059	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Developmental And Epileptic Encephalopathy 30	DEE30 Epileptic Encephalopathy, Early Infantile, 30 Eiee30 Developmental And Epileptic Encephalopathy, 30 Early Infantile Epileptic Encephalopathy 30 Encephalopathy, Epileptic, Early Infantile, Type 30
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Suppression Bursts Early Infantile Epileptic Encephalopathy With Burst-Suppression Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Early Myoclonic Encephalopathy	Myoclonic Epilepsy Myoclonic Seizure Epilepsies, Myoclonic Epileptic Seizures - Myoclonic Epileptic Seizures, Myoclonic Myoclonia Epileptica Myoclonic Seizure Disorder Early Myoclonic Encephalopathy With Suppression-Bursts
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-15776	HG-9-91-01	Inhibitor	99.77%	Unkown
HY-101147	YKL-05-099	Inhibitor	99.76%	Unkown
HY-120877	MRT199665	Inhibitor	99.85%	Unkown
HY-120856	ARN-3236	Inhibitor	99.66%	Unkown
HY-120056	YKL-06-061	Inhibitor	99.82%	Unkown
HY-175479	GLPG4970	Inhibitor	99.60%	Unkown
HY-139253	MRIA9	Inhibitor	98.88%	Unkown
HY-171591	SIK2-IN-4	Inhibitor	99.06%	Unkown
HY-182804	SIK2/3-IN-3	Inhibitor	/	Unkown
HY-171590	SIK2-IN-3	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SIK1	RGD	RGD:69407
Mus musculus	SIK1	MGD	MGI:104754