BCAN - brevican Gene

Also Known as BEHAB; CSPG7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63827

About BCAN

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,642,117-156,659,528 (from NCBI)

This gene has 8 transcripts (splice variants), 272 orthologues and 7 paralogues. Restricted expression toward brain (RPKM 121.6).

Summary

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

BCAN Products (2)

mRNA Protein Name
NM_021948.5 NP_068767.3 brevican core protein isoform 1 precursor
NM_198427.2 NP_940819.1 brevican core protein isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAN Protein Structure

V-set

V-set: Immunoglobulin V-set domain (43 - 142)

Xlink

Xlink: Extracellular link domain (156 - 251)

Xlink

Xlink: Extracellular link domain (257 - 353)

EGF

EGF: EGF-like domain (650 - 679)

Lectin_C

Lectin_C: Lectin C-type domain (706 - 810)

Sushi

Sushi: Sushi repeat (SCR repeat) (815 - 871)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
Protein Preferred Names Protein Names

brevican core protein

  • brain-enriched hyaluronan-binding protein

BCAN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
BCAN Q96GW7 LYN Homo sapiens P07948
Y2H Array
32814053
Intra
BCAN Q96GW7 LYN Homo sapiens P07948
Y2H Pooling
32814053
Intra
BCAN Q96GW7 LYN Homo sapiens P07948
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCAN Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7676 BCAN Protein, Human (HEK293, His) Q96GW7-1 (D23-P911) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Normal Pressure Hydrocephalus

  • Low Pressure Hydrocephalus

  • Hydrocephalus Normal Pressure

  • Hydrocephalus, Normal Pressure

  • Normal Pressure Hydrocephalus Nos

  • Nph - [Normal Pressure Hydrocephalus]

  • Normal Pressure Hydrocephaly
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Gliosarcoma

  • Glioblastoma With Sarcomatous Component

  • Sarcomatous Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS18912 Bcan Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-166833 DOPE-PEG5000-Rhodamine B / Unkown
HY-RS01394 BCAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25403 Bcan Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BCAN VGNC VGNC:38395
Felis catus BCAN VGNC VGNC:60077
Mus musculus BCAN MGD MGI:1096385
Bos taurus BCAN VGNC VGNC:26434
Macaca mulatta BCAN VGNC VGNC:70112
Rattus norvegicus BCAN RGD RGD:2194
Others BCAN NCBI