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Art. -Nr.: HY-189004

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SLU-11695

SLU-11695 is an orally active antiparasitic agent belonging to the pyrazolo[3,4-d]pyrimidine benzoxaborole class. SLU-11695 inhibits the asexual reproduction of Cryptosporidium parvum, eliminates parasite shedding, and prevents post-exposure recurrence. SLU-11695 can be used in the research of cryptosporidiosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3065121-95-8
Formel: C₂₃H₂₃BFN₅O₂
Molecular Weight:431.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SLU-11695 Chemical Structure

CAS. Nr.: 3065121-95-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	EC50	0.025 μM	Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period. Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.	42593902
HCT-8	CC₅₀	~77 μM	Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound. Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.	42593902

In Vitro

SLU-11695 (0.025 μM; 48 h) potently inhibits Cryptosporidium parvum growth in HCT-8 cells with an EC₅₀ of 0.025 μM and exhibits >3000-fold selectivity over host cell cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SLU-11695 (50 mg/kg; p.o.; twice daily; 4 days) achieves curative efficacy in immunocompromised NSG mice with chronic Cryptosporidium parvum infection, eliminating parasite shedding with no observed relapse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (male, 4-5 weeks old)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; twice daily; 4 days
Result:

Eliminated *C. parvum* fecal shedding with no evidence of relapse up to 8 days after dosing cessation.
Showed no apparent side effects in all tested mice.

Chemical Information

CAS. Nr. 3065121-95-8
Molecular Weight 431.27
Formel C₂₃H₂₃BFN₅O₂
SMILES

CCC1=NN(C)C2=NC(C3=CC=C(B(O)OC4C)C4=C3)=NC(NCC5=CC=C(F)C=C5)=C21
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Guin S, et al. Structure-Activity Relationship Study of Anti-Cryptosporidium Benzoxaboroles Yields Enhanced Potency and Curative Efficacy. Journal of medicinal chemistry. 2026 Aug 13;69(15):19355-19370.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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