630124-46-8
630124-46-8
Chemical Structure
AST 487
Synonym(s): NVP-AST 487
- CAS No.: 630124-46-8
- Formula:C26H30F3N7O2
- Molecular Weight:529.56
IUPAC Name: 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea
InChIKey: ODPGGGTTYSGTGO-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC2=NC=NC(NC)=C2)C=C1)NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3
Biological Activity: AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
AST 487 | 98.90% | AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
