Prospero homeobox protein 1
Definition:
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
References:
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[1]. Tamador Elsir, et al. Transcription factor PROX1: its role in development and cancer. Cancer Metastasis Rev. 2012 Dec;31(3-4):793-805. [Content Brief]
[2]. Yukimasa Takeda, et al. Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation. Nucleic Acids Res. 2013 Aug;41(14):6992-7008. [Content Brief]
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