Zinc finger protein RFP

Definition:

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

References:

[1]. So Hee Dho, et al. The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif. J Biol Chem. 2003 Aug 22;278(34):31902-8. [Content Brief]

[2]. Yi-Heng Hao, et al. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 2013 Feb 28;152(5):1051-64. [Content Brief]

[3]. Y Shimono, et al. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. J Biol Chem. 2000 Dec 15;275(50):39411-9. [Content Brief]

[4]. Xinjiang Cai, et al. Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20072-7. [Content Brief]

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