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  4. BM 15766 sulfate

BM 15766 sulfate is an inhibitor of 7-dehydrocholesterol δ7-reductase and reduces plasma cholesterol levels. BM 15766 sulfate is a hypolipidemic agent.

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BM 15766 sulfate

BM 15766 sulfate Estructura química

No. CAS : 86621-94-5

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Descripciòn

BM 15766 sulfate is an inhibitor of 7-dehydrocholesterol δ7-reductase and reduces plasma cholesterol levels. BM 15766 sulfate is a hypolipidemic agent[1][2].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
500 nM
Compound: BM 15.766 sulfate
Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 24 hrs GC/MS analysis
Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 24 hrs GC/MS analysis
[PMID: 22882119]
Peso molecular

482.98

Fòrmula

C22H27ClN2O6S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(CCN2CCN(C/C=C/C3=CC=C(Cl)C=C3)CC2)C=C1.O=S(O)(O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (207.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0705 mL 10.3524 mL 20.7048 mL
5 mM 0.4141 mL 2.0705 mL 4.1410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
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Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0705 mL 10.3524 mL 20.7048 mL 51.7620 mL
5 mM 0.4141 mL 2.0705 mL 4.1410 mL 10.3524 mL
10 mM 0.2070 mL 1.0352 mL 2.0705 mL 5.1762 mL
15 mM 0.1380 mL 0.6902 mL 1.3803 mL 3.4508 mL
20 mM 0.1035 mL 0.5176 mL 1.0352 mL 2.5881 mL
25 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0705 mL
30 mM 0.0690 mL 0.3451 mL 0.6902 mL 1.7254 mL
40 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.2940 mL
50 mM 0.0414 mL 0.2070 mL 0.4141 mL 1.0352 mL
60 mM 0.0345 mL 0.1725 mL 0.3451 mL 0.8627 mL
80 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6470 mL
100 mM 0.0207 mL 0.1035 mL 0.2070 mL 0.5176 mL
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BM 15766 sulfate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BM 1576686621-94-5BM15766BM-15766Drug DerivativeDrug derivativeCholesterolhypolipidemicInhibitorinhibitorinhibit

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Nombre del producto:
BM 15766 sulfate
Cat. No.:
HY-137318
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