280749-17-9
280749-17-9
Chemical Structure
A-286982
- CAS No.: 280749-17-9
- Formula:C24H27N3O4S
- Molecular Weight:453.55
IUPAC Name: (E)-1-(4-acetylpiperazin-1-yl)-3-(4-((2-isopropylphenyl)thio)-3-nitrophenyl)prop-2-en-1-one
InChIKey: HTGGAYLWTDOFDK-PKNBQFBNSA-N
SMILES: O=[N+]([O-])C(C=C(C=C1)/C=C/C(N2CCN(CC2)C(C)=O)=O)=C1SC3=C(C=CC=C3)C(C)C
Biological Activity: A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A-286982 | 98.12% | A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively. | ||||||||||||||||||||
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References
- [1]. G Liu, et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J Med Chem. 2000 Oct 19;43(21):4025-40. [Content Brief]
- [2]. Susan M Keating, et al. Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. Protein Sci. 2006 Feb;15(2):290-303. [Content Brief]
