2913194-20-2
Chemical Structure
Antiproliferative agent-52
- CAS No.: 2913194-20-2
- Formula:C14H12ClN3OS
- Molecular Weight:305.78
InChIKey: HORXFYJUOOLKSX-UHFFFAOYSA-N
SMILES: COC1=CC=C(N(C2=NC(Cl)=NC3=C2SC=C3)C)C=C1
Biological Activity: Antiproliferative agent-52 is a tubulin inhibitor with a porcine tubulin KD of 29.65 μM. Antiproliferative agent-52 binds to the colchicine-binding site at the α-tubulin and β-tubulin interface and inhibits tubulin polymerization. Antiproliferative agent-52 exhibits antiproliferative activity against tumor cells. Antiproliferative agent-52 serves as a lead compound for development of thienopyrimidine and heterocyclic fused pyrimidines with antiproliferative activity. Antiproliferative agent-52 can be used for the research of ovarian cancer, non-small cell lung cancer[1].
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Antiproliferative agent-52 | Antiproliferative agent-52 is a tubulin inhibitor with a porcine tubulin KD of 29.65 μM. Antiproliferative agent-52 binds to the colchicine-binding site at the α-tubulin and β-tubulin interface and inhibits tubulin polymerization. Antiproliferative agent-52 exhibits antiproliferative activity against tumor cells. Antiproliferative agent-52 serves as a lead compound for development of thienopyrimidine and heterocyclic fused pyrimidines with antiproliferative activity. Antiproliferative agent-52 can be used for the research of ovarian cancer, non-small cell lung cancer. | |||||||||||||||||||||
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