3378-93-6
3378-93-6
Chemical Structure
Clociguanil
Synonym(s): BRL 50216
- CAS No.: 3378-93-6
- Formula:C12H15Cl2N5O
- Molecular Weight:316.19
IUPAC Name: 1-((3,4-dichlorobenzyl)oxy)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
InChIKey: XDTNOYLBDDCJSK-UHFFFAOYSA-N
SMILES: NC1=NC(N)=NC(C)(N1OCC2=CC=C(C(Cl)=C2)Cl)C
Biological Activity: Clociguanil (BRL 50216), a DHFR inhibitor (IC50: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Clociguanil | Clociguanil (BRL 50216), a DHFR inhibitor (IC50: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action. | |||||||||||||||||||||
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References
- [1]. Nettleton MJ, et al. The cardiovascular effects of two new triazine antimalarials, BRL 50216 (Clociguanil) and BRL 6231. Toxicol Appl Pharmacol. 1974 Feb;27(2):271-82. [Content Brief]
- [2]. Winstanley PA, et al. In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52. [Content Brief]
