AChE-IN-62
AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1-42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease.
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- Formule: C19H21N5O3S2
- Masse moléculaire:431.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 0.421 μM (AChE)[1].
In Vitro
AChE-IN-62 (50 μM; 24-48 h) effectively inhibits the aggregation of Aβ1−42 with an IC50 value of 44.64 μM[1].
AChE-IN-62 (5-20 μM; 24 h) demonstrates neuroprotective effects in SH-SY5Y and Neuro2A cells by ameliorating the neurotoxic effects mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785) (30 nM; 24 h)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y, Neuro2A
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Concentration:5 μM, 10 μM, 20 μM;
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Incubation Time:24 h
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Result:Inhibited the cell death mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dementia model of Swiss albino mice mediated by scopolamine[1].
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Dosage:5 mg/kg, 10 mg/kg
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Administration:Intraperitoneal injection (i.p.); Once daily for 7 days. Before scopolamine (HY-N0296) treatment (3 mg/kg; i.p.; Once daily for 7 days)
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Result:Reduced the recognition ratio (T2/T1) in mice (a lower T2/T1 value indicates stronger short-term recognition memory).
Significantly enhanced the step-through latency (STL) (a decrease in STL indicates impaired memory).
Chemical Information
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Masse moléculaire 431.53
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Formule C19H21N5O3S2
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SMILES
CS(C1=CC=C2C(SC(NC(CN3CCN(C4=CC=CC=N4)CC3)=O)=N2)=C1)(=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-62 Related Classifications
HY-161466 Related Classifications
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