country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187734

Copy Link Print Information

AY 17605

AY 17605 is a nucleoside-3':5'-monophosphate phosphodiesterase (Phosphodiesterase) inhibitor that blocks cAMP hydrolysis through non-competitive inhibition, thereby elevating intracellular cAMP levels. AY 17605 can be used in studies related to cardiotonic activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 7755-28-4
Formule: C₂₅H₃₆O₅
Masse moléculaire:416.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY 17605 Chemical Structure

CAS No.: 7755-28-4

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

In Vitro

AY 17605 (preincubation 5 min; PDE reaction 1 min) is a potent non-competitive inhibitor of purified bovine heart nucleoside-3':5'-monophosphate phosphodiesterase, with an IC₅₀ of 44 μM^[1].
AY 17605 (0.1 μM; 5 min preincubation, 1.5 min PDE reaction) exhibits only weak inhibitory activity against purified rat brain nucleoside-3':5'-monophosphate phosphodiesterase^[1].
AY 17605 is a non-competitive inhibitor of bovine heart nucleoside-3':5'-monophosphate phosphodiesterase, with an IC₅₀ of 44 μM and a K_i of 0.064 μM^[2].
AY 17605 (0.1 μM) exhibits only moderate inhibitory activity against rat brain nucleoside-3':5'-monophosphate phosphodiesterase, producing 24% inhibition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7755-28-4
Masse moléculaire 416.56
Formule C₂₅H₃₆O₅
SMILES

O[C@@]12[C@@](C)([C@H](CC1)C=3C(=O)OCC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](OC(C)=O)C5)[H])[H])[H]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lippmann W. Inhibition of beef heart and rat brain nucleoside-3':5'-monophosphate phosphodiesterase by 3beta-14-dihydroxy-21-oxo-23-desoxo-5-beta-card-20(22)-enolide 3-acetate (AY-17,605) and structurally related compounds. Experientia. 1974 Mar 15;30(3):237-9.

[2]. Balogun RA. Amino acids in the excreta of the tsetse fly, Glossina palpalis. Experientia. 1974 Mar 15;30(3):239-40.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis