Meayamycin B
Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer.
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- CAS No.: 1020210-12-1
- Formule: C31H48N2O8
- Masse moléculaire:576.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Mcl-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.49 nM
Compound: 96
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Cytotoxicity against human HCT-116 cells assessed as inhibition in cell growth
Cytotoxicity against human HCT-116 cells assessed as inhibition in cell growth
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[PMID: 33974423] |
| HCT-116/VM46 | IC50 |
0.55 nM
Compound: 96
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Cytotoxicity against human HCT116/VM46 cells assessed as inhibition in cell growth
Cytotoxicity against human HCT116/VM46 cells assessed as inhibition in cell growth
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[PMID: 33974423] |
| L1210 | IC50 |
7.8 nM
Compound: 96
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Cytotoxicity against mouse L1210 cells assessed as inhibition in cell growth
Cytotoxicity against mouse L1210 cells assessed as inhibition in cell growth
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[PMID: 33974423] |
Chemical Information
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CAS No. 1020210-12-1
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Masse moléculaire 576.72
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Formule C31H48N2O8
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SMILES
O[C@H]1[C@@]2(CC(C)(O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(N4CCOCC4)=O)=O)C)C)CO2
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Synonyms
(+)-Meayamycin B
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Meayamycin B Related Classifications
HY-15867 Related Classifications
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