Multitarget AD-IN-3
Multitarget AD-IN-3 is a brain-penetrant neuroprotective agent. Multitarget AD-IN-3 can selectively inhibit MAO-B with an IC50 of 4.42 μM and a SI of 18.12. Multitarget AD-IN-3 can eliminate ROS. Multitarget AD-IN-3 Multitarget AD-IN-3 can inhibit Aβ1-42 self-aggregation and can reverse Aβ1-42-induced mitochondrial membrane depolarization and inhibit apoptosis. Multitarget AD-IN-3 can be used for the research of neurological disease, such as Alzheimer’s disease.
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- Formule: C19H17N7O4
- Masse moléculaire:407.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MAO-B 4.42 μM (IC50) |
MAO-A 80.21 μM (IC50) |
COX |
Multitarget AD-IN-3 (10 μM) significantly inhibits the production of NO, TNF-α, and IL-6 in LPS-stimulated RAW 264.7 and BV-2 cells and downregulates the expression of COX-2 and NF-κB[1].
Multitarget AD-IN-3 (10 μM) significantly reduces intracellular ROS accumulation induced by TBHP in SH-SY5Y cells[1].
Multitarget AD-IN-3 can chelate Al3+, Cu2+, Fe2+, and Zn2+[1].
Multitarget AD-IN-3 (25-50 μM, 24 h) dose-dependently inhibits Aβ1-42 self-aggregation[1].
Multitarget AD-IN-3 (10 μM, 18-24 h) can reverse Aβ1-42-induced mitochondrial membrane depolarization, inhibit apoptosis and enhance the viability in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:10 μM
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Incubation Time:18 h
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Result:Increased the JC-1 red/green fluorescence ratio.
Chemical Information
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Masse moléculaire 407.38
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Formule C19H17N7O4
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SMILES
O=C(N/N=C/C1=CC=CN1)C(N=NN2C(C=C3)=CC=C3NC(/C=C/C(O)=O)=O)=C2C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multitarget AD-IN-3 Related Classifications
HY-178454 Related Classifications
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