Sp-cAMPS triethylamine
Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC50 of 40 μM.
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- CAS No.: 93602-66-5
- Formule: C16H27N6O5PS
- Masse moléculaire:446.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-12306
8-Bromo-cAMP sodium salt
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HY-B0764
Bucladesine sodium
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HY-100530
Rp-cAMPS triethylammonium salt
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HY-103322
6-Bnz-cAMP sodium salt
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HY-111673
8-CPT-Cyclic AMP sodium
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HY-12306A
8-Bromo-cAMP
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HY-W012980
Isovaleric acid
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HY-W012980R
Isovaleric acid (Standard)
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HY-B0764R
Bucladesine sodium (Standard)
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HY-B1898
Metadoxine
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HY-100530D
Rp-cAMPS sodium salt
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HY-101379A
8-Bromo-cGMP sodium
Activité biologique
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PKA I |
PKA II |
PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC50) |
Treatment of hepatocytes with Sp-cAMPS triethylamine, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca2+ can be mimicked by Sp-cAMPS triethylamine[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 93602-66-5
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Masse moléculaire 446.46
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Formule C16H27N6O5PS
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SMILES
O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3.CCN(CC)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30(1):16-31. [Content Brief]
[2]. L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253(5024):1132-5. [Content Brief]
[3]. Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287(2):1210-9. [Content Brief]
[4]. P A Connelly,et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32. [Content Brief]
[5]. G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sp-cAMPS triethylamine Related Classifications
HY-110005 Related Classifications
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