Cat. No.: HY-N6725

Sterigmatocystine

Avis client

Based on 1 Customer Validation

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.74%
CAS No.: 10048-13-2
Formule: C₁₈H₁₂O₆
Masse moléculaire:324.28

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sterigmatocystine Chemical Structure

CAS No.: 10048-13-2

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor^[1]^[2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals^[3].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Voir tous les produits spécifiques à Isoform Antibiotic :

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	3.63 μM Compound: 7	Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
MDA-MB-231	IC₅₀	2.75 μM Compound: 7	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
NCI-H460	IC₅₀	3.41 μM Compound: 7	Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
PC-3M	IC₅₀	3.23 μM Compound: 7	Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
SF-268	IC₅₀	2.96 μM Compound: 7	Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]

In Vitro

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21^WAF1/CIP1^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10048-13-2
Appearance Solid
Masse moléculaire 324.28
Formule C₁₈H₁₂O₆
Color Off-white to light yellow
SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[C@]5([H])[C@@]4([H])C=CO5)C=C2OC
Structure Classification
- Phenols
- Monophenols
- Phenols
- Xanthones
Initial Source
- Microorganisms
Aspergillus versicolor
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 25 mg/mL (77.09 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0838 mL

15.4188 mL

30.8375 mL

5 mM

0.6168 mL

3.0838 mL

6.1675 mL

10 mM

0.3084 mL

1.5419 mL

3.0838 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31. [Content Brief]

[2]. Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91. [Content Brief]

[3]. Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656. [Content Brief]

[4]. Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0838 mL	15.4188 mL	30.8375 mL	77.0939 mL
	5 mM	0.6168 mL	3.0838 mL	6.1675 mL	15.4188 mL
	10 mM	0.3084 mL	1.5419 mL	3.0838 mL	7.7094 mL
	15 mM	0.2056 mL	1.0279 mL	2.0558 mL	5.1396 mL
	20 mM	0.1542 mL	0.7709 mL	1.5419 mL	3.8547 mL
	25 mM	0.1234 mL	0.6168 mL	1.2335 mL	3.0838 mL
	30 mM	0.1028 mL	0.5140 mL	1.0279 mL	2.5698 mL
	40 mM	0.0771 mL	0.3855 mL	0.7709 mL	1.9273 mL
	50 mM	0.0617 mL	0.3084 mL	0.6168 mL	1.5419 mL
	60 mM	0.0514 mL	0.2570 mL	0.5140 mL	1.2849 mL

Keywords

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Sterigmatocystine

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Anti-Cancer Compound Library

Human Endogenous Metabolite Compound Library

Anti-Aging Compound Library

Lipid Compound Library

Antibacterial Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Antibiotics Library

Microbial Metabolite Library

Tumorigenesis-Related Compound Library

Anti-Cancer Natural Product Library

Human Metabolite Library

Animal-Sourced Natural Product Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Fungal-Sourced Compound Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Voir tous les produits spécifiques à Isoform Antibiotic

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Sterigmatocystine Related Classifications

HY-N6725 Related Classifications