Calpain Inhibitor-2
Calpain Inhibitor-2 (compound 5) is a peptide inhibitor of μ-calpain (Ki=9 nM). Calpain Inhibitor-2 exhibits antiproliferative activity against melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells in vitro.
For research use only. We do not sell to patients.
- CAS No.: 2413962-65-7
- Formula: C26H33N3O5S
- Molecular Weight:499.62
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Calcium Channel Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | GI50 |
16 μM
Compound: 5
|
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
|
[PMID: 32199690] |
| B16-F1 | GI50 |
17.2 μM
Compound: 5
|
Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
|
[PMID: 32199690] |
| PC-3 | GI50 |
6.02 μM
Compound: 5
|
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
|
[PMID: 32199690] |
Chemical Information
-
CAS No. 2413962-65-7
-
Molecular Weight 499.62
-
Formula C26H33N3O5S
-
SMILES
CC(C[C@@H](C(C(N)=O)=O)NC([C@H](C(C)C)NS(=O)(C1=CC=C(C=C1)/C=C/C2=CC=CC=C2)=O)=O)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)