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製品番号: HY-147734

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Calpain Inhibitor-2

Calpain Inhibitor-2 (compound 5) is a peptide inhibitor of μ-calpain (Ki=9 nM). Calpain Inhibitor-2 exhibits antiproliferative activity against melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells in vitro.

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CAS 番号: 2413962-65-7
分子式: C₂₆H₃₃N₃O₅S
分子量:499.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Calpain Inhibitor-2 構造式

CAS 番号: 2413962-65-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Calcium Channel アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	GI₅₀	16 μM Compound: 5	Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay	[PMID: 32199690]
B16-F1	GI₅₀	17.2 μM Compound: 5	Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay	[PMID: 32199690]
PC-3	GI₅₀	6.02 μM Compound: 5	Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 32199690]

化学情報

CAS 番号 2413962-65-7
分子量 499.62
分子式 C₂₆H₃₃N₃O₅S
SMILES

CC(C[C@@H](C(C(N)=O)=O)NC([C@H](C(C)C)NS(=O)(C1=CC=C(C=C1)/C=C/C2=CC=CC=C2)=O)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Donkor IO,et al. Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors. Bioorg Med Chem. 2020 May 1;28(9):115433. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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参考文献

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Calpain Inhibitor-2

Calcium Channel アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Calpain Inhibitor-2 関連分類

HY-147734 関連分類