100891-41-6
Chemical Structure
Ro 14-9578
- CAS No.: 100891-41-6
- Formula:C16H13NO5
- Molecular Weight:299.28
IUPAC Name: 6-methyl-2-oxo-6,7-dihydro-2H-[1,3]dioxolo[4,5-g]pyrido[2,1-a]isoquinoline-3-carboxylic acid
InChIKey: DJUJOTVZFFTBPC-UHFFFAOYSA-N
SMILES: O=C(C1=CN2C(C3=C(CC2C)C=C4OCOC4=C3)=CC1=O)O
Biological Activity: Ro 14-9578 is a tricyclic quinolone analog with antibacterial activity. Ro 14-9578 inhibits DNA biosynthesis (IC50=117 μM) and DNA supercoiling (IC50=66.8 μM) in Escherichia coli. Furthermore, Ro 14-9578 exhibits inhibitory effects against various Gram-negative bacteria and Staphylococcus aureus[1].
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Ro 14-9578 | Ro 14-9578 is a tricyclic quinolone analog with antibacterial activity. Ro 14-9578 inhibits DNA biosynthesis (IC50=117 μM) and DNA supercoiling (IC50=66.8 μM) in Escherichia coli. Furthermore, Ro 14-9578 exhibits inhibitory effects against various Gram-negative bacteria and Staphylococcus aureus. | |||||||||||||||||||||
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Keywords
