1023875-75-3
Chemical Structure
Tubulin inhibitor 49
- CAS No.: 1023875-75-3
- Formula:C18H14F3N3OS
- Molecular Weight:377.38
InChIKey: WCPMDFWXUJATQO-UHFFFAOYSA-N
SMILES: O=C(C)NC1=CC=C(C2=CSC(NC3=CC=CC(C(F)(F)F)=C3)=N2)C=C1
Biological Activity: Tubulin inhibitor 49 (Compound 18) is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell). Tubulin inhibitor 49 can be used in the research of cervical cancer[1].
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Tubulin inhibitor 49 | Tubulin inhibitor 49 (Compound 18) is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell). Tubulin inhibitor 49 can be used in the research of cervical cancer. | |||||||||||||||||||||
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Keywords