1025795-12-3
Chemical Structure
JNJ-27390467
- CAS No.: 1025795-12-3
- Formula:C33H30N2O5
- Molecular Weight:534.60
IUPAC Name: (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidin]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone benzoate
InChIKey: BOSSCQOUHQQZCJ-UHFFFAOYSA-N
SMILES: NCC1=CC=C(OCC23CCN(C(C4=CC=C(C#CC5=CC=CC=C5)O4)=O)CC3)C2=C1.OC(C6=CC=CC=C6)=O
Biological Activity: JNJ-27390467 is a potent, orally active, and selective tryptase inhibitor (human β-tryptase IC50 = 3.6 nM, Ki = 3.7 nM). JNJ-27390467 exhibits excellent selectivity over trypsin of ~5000-fold. JNJ-27390467 shows effects in animal models of airway inflammation. JNJ-27390467 can be used for allergic asthma research[1].
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JNJ-27390467 | JNJ-27390467 is a potent, orally active, and selective tryptase inhibitor (human β-tryptase IC50 = 3.6 nM, Ki = 3.7 nM). JNJ-27390467 exhibits excellent selectivity over trypsin of ~5000-fold. JNJ-27390467 shows effects in animal models of airway inflammation. JNJ-27390467 can be used for allergic asthma research. | |||||||||||||||||||||
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Keywords
