1027102-50-6
Chemical Structure
UGM-IN-1
- CAS No.: 1027102-50-6
- Formula:C18H13Cl2IN2O2S
- Molecular Weight:519.18
IUPAC Name: 2-((4-(3,4-dichlorophenyl)thiazol-2-yl)amino)-3-(4-iodophenyl)propanoic acid
InChIKey: KCANQQYJEXKIFP-UHFFFAOYSA-N
SMILES: O=C(O)C(NC1=NC(=CS1)C=2C=CC(Cl)=C(Cl)C2)CC3=CC=C(I)C=C3
Biological Activity: UGM-IN-1 (compound 107) is a selective competitive inhibitor of Mycobacterium tuberculosis UDP-Galp mutase (UGM), encoded by Rv3809c. UGM-IN-1 inhibits the conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf), thereby blocking the synthesis of key components of the mycobacterial cell wall, including mycolic acid-arabinogalactan (mAG) and liparabinomannan (LAM), leading to anti-mycobacterial activity against Mycobacterium tuberculosis. UGM-IN-1 is useful for research on tuberculosis, including drug-resistant tuberculosis [1].
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UGM-IN-1 | UGM-IN-1 (compound 107) is a selective competitive inhibitor of Mycobacterium tuberculosis UDP-Galp mutase (UGM), encoded by Rv3809c. UGM-IN-1 inhibits the conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf), thereby blocking the synthesis of key components of the mycobacterial cell wall, including mycolic acid-arabinogalactan (mAG) and liparabinomannan (LAM), leading to anti-mycobacterial activity against Mycobacterium tuberculosis. UGM-IN-1 is useful for research on tuberculosis, including drug-resistant tuberculosis . | |||||||||||||||||||||
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Keywords
