103882-87-7
Chemical Structure
LY 223592
Synonym(s): dFdG
- CAS No.: 103882-87-7
- Formula:C10H11F2N5O4
- Molecular Weight:303.22
IUPAC Name: 2-amino-9-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
InChIKey: RQIYMUKKPIEAMB-TWOGKDBTSA-N
SMILES: O=C1C(N=CN2[C@H]3C(F)(F)[C@H](O)[C@@H](CO)O3)=C2NC(N)=N1
Biological Activity: LY 223592 (Compound I-a) is a Gemcitabine (HY-17026) derivative. LY 223592 has the biological activity of highly selective inhibition of lung cancer cell proliferation (IC50 = 5.6 nM in A549 cells) and low cytotoxicity to normal cells. LY 223592 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC)[1].
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LY 223592 | LY 223592 (Compound I-a) is a Gemcitabine (HY-17026) derivative. LY 223592 has the biological activity of highly selective inhibition of lung cancer cell proliferation (IC50 = 5.6 nM in A549 cells) and low cytotoxicity to normal cells. LY 223592 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC). | |||||||||||||||||||||
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Keywords
