104926-84-3
Chemical Structure
GlmU-IN-1
- CAS No.: 104926-84-3
- Formula:C9H7Cl2N3O
- Molecular Weight:244.08
IUPAC Name: 5,7-dichloro-2-hydrazinylquinolin-8-ol
InChIKey: GEMKVFRCPIKGPF-UHFFFAOYSA-N
SMILES: OC1=C2N=C(C=CC2=C(C=C1Cl)Cl)NN
Biological Activity: GlmU-IN-1 is an inhibitor of the GlmU acetyltransferase domain in Escherichia coli and Haemophilus influenzae. GlmU-IN-1 acts as a competitive inhibitor of AcCoA and a non-competitive inhibitor of GlcN-1-P. GlmU-IN-1 targets the acetyltransferase domain of bacterial GlmU, interferes with the biosynthesis of UDP‑GlcNAc, and impairs bacterial cell wall integrity. GlmU-IN-1 can be used for the research of Gram-negative bacterial infections[1].
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GlmU-IN-1 | GlmU-IN-1 is an inhibitor of the GlmU acetyltransferase domain in Escherichia coli and Haemophilus influenzae. GlmU-IN-1 acts as a competitive inhibitor of AcCoA and a non-competitive inhibitor of GlcN-1-P. GlmU-IN-1 targets the acetyltransferase domain of bacterial GlmU, interferes with the biosynthesis of UDP‑GlcNAc, and impairs bacterial cell wall integrity. GlmU-IN-1 can be used for the research of Gram-negative bacterial infections. | |||||||||||||||||||||
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