1082954-71-9
1082954-71-9
Chemical Structure
A-987306
- CAS No.: 1082954-71-9
- Formula:C18H25N5O
- Molecular Weight:327.42
IUPAC Name: (7aS,11aS)-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine
InChIKey: DJKJVWJQAVGLHJ-YPMHNXCESA-N
SMILES: NC1=NC(N2CCNCC2)=C3CCC(O[C@]4([H])[C@@]5([H])CCCC4)=C5C3=N1
Biological Activity: A-987306 is a potent and oral bioavailable histamine H4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 shows anti-inflammatory activity in mice peritonitis model[1].
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A-987306 | A-987306 is a potent and oral bioavailable histamine H4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 shows anti-inflammatory activity in mice peritonitis model. | |||||||||||||||||||||
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References
Keywords
