1095003-80-7
Chemical Structure
p38α inhibitor 2
- CAS No.: 1095003-80-7
- Formula:C27H33N5O3
- Molecular Weight:475.58
IUPAC Name: N-cyclopropyl-4-methyl-3-(3-((2-(2-(2-(methylamino)ethoxy)phenyl)propan-2-yl)amino)-2-oxopyrazin-1(2H)-yl)benzamide
InChIKey: SAZVRXTVWZAHBI-UHFFFAOYSA-N
SMILES: O=C(NC1CC1)C2=CC=C(C)C(N3C(C(NC(C4=CC=CC=C4OCCNC)(C)C)=NC=C3)=O)=C2
Biological Activity: p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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p38α inhibitor 2 | 98.33% | p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets. | ||||||||||||||||||||
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