111113-75-8
Chemical Structure
5,6,7,8-Tetrahydro-8-deazahomofolic acid
- CAS No.: 111113-75-8
- Formula:C21H26N6O6
- Molecular Weight:458.47
IUPAC Name: (4-((2-((R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[3,2-d]pyrimidin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
InChIKey: KWOGIKPULGQYDN-HIFRSBDPSA-N
SMILES: O=C1C2=C(NC(N)=N1)CC[C@@H](N2)CCNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
Biological Activity: 5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase[1].
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5,6,7,8-Tetrahydro-8-deazahomofolic acid | 5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase. | |||||||||||||||||||||
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