111696-23-2
Chemical Structure
Cefetamet pivoxil hydrochloride
Synonym(s): Ro 15-8075
- CAS No.: 111696-23-2
- Formula:C20H26ClN5O7S2
- Molecular Weight:548.03
IUPAC Name: (pivaloyloxy)methyl (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
InChIKey: XAAOHMIKXULDKJ-IZXJIOGHSA-N
SMILES: O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O.Cl
Biological Activity: Cefetamet pivoxyl hydrochloride (Ro 15-8075) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl hydrochloride is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl hydrochloride is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, Neisseria, Haemophilus) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl hydrochloride exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cefetamet pivoxil hydrochloride | 98.0% | Cefetamet pivoxyl hydrochloride (Ro 15-8075) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl hydrochloride is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl hydrochloride is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, Neisseria, Haemophilus) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl hydrochloride exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae). | ||||||||||||||||||||
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Cefetamet pivoxil hydrochloride (Standard) | ≥98% | Cefetamet pivoxil (hydrochloride) (Standard) (Ro 15-8075 (Standard)) is the analytical standard of Cefetamet pivoxil (hydrochloride) (HY-B1894A). This product is intended for research and analytical applications. Cefetamet pivoxyl hydrochloride (Ro 15-8075) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl hydrochloride is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl hydrochloride is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, Neisseria, Haemophilus) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl hydrochloride exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae). | ||||||||||||||||||||
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References
- [1]. Hohl P, et al. Cefetamet pivoxil: bacteriostatic and bactericidal activity of the free acid against 355 gram-negative rods. Infection. 1988;16(3):194-198. [Content Brief]
- [2]. Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993 Apr;45(4):589-621. [Content Brief]
