112856-39-0
112856-39-0
Chemical Structure
FR 78844
- CAS No.: 112856-39-0
- Formula:C8H9NNa2O6P2S
- Molecular Weight:355.15
IUPAC Name: sodium (2-(phenylamino)-1-phosphono-2-thioxoethyl)phosphonate
InChIKey: KTGBYROLTNECAS-UHFFFAOYSA-L
SMILES: S=C(NC1=CC=CC=C1)C(P(O)(O)=O)P(O[Na])(O[Na])=O
Biological Activity: FR 78844 is an orally active bone resorption inhibitor. FR 78844 attenuates metaphyseal bone mineral density decreases in Streptozotocin (HY-13753)-induced diabetic rats, and Heparin (HY-17567A)-induced osteopenia, but does not affect vitamin D-deficient rat bone loss. FR 78844 can be used for the research of osteopenia[1][2].
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FR 78844 | FR 78844 is an orally active bone resorption inhibitor. FR 78844 attenuates metaphyseal bone mineral density decreases in Streptozotocin (HY-13753)-induced diabetic rats, and Heparin (HY-17567A)-induced osteopenia, but does not affect vitamin D-deficient rat bone loss. FR 78844 can be used for the research of osteopenia. | |||||||||||||||||||||
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References
- [1]. Takeshita N, et al. Possible involvement of vitamin D3-deficiency and relatively enhanced bone resorption in the development of bone loss in streptozotocin-induced diabetic rats. Life Sci. 1994;55(4):291-9. [Content Brief]
- [2]. Mutoh S, et al. Characterization of heparin-induced osteopenia in rats. Endocrinology. 1993 Dec;133(6):2743-8. [Content Brief]
